拜阿司匹林联合氯吡格雷治疗急性轻型脑梗死的临床疗效及不良反应分析

Clinical Efficacy and Side Effects of Aspirin and Clopidogrel in the Treatment of Acute Mild Cerebral Infarction

目的:观察拜阿司匹林与氯吡格雷联合治疗急性轻型脑梗死患者的临床效果及药物不良反应发生情况。方法:选择2019年1月~12月期间某院收治的60例急性轻型脑梗死患者作为研究对象,以随机数字表法分为对照组和观察组各30例,在常规内科治疗基础上,对照组给予阿司匹林肠溶片治疗,观察组给予氯吡格雷联合阿司匹林肠溶片治疗,观察并比较两组患者的神经功能、不良反应、疗效等。结果:治疗前,所有患者神经缺损功能各项评分均无显著差异(P>0.05),治疗后,各项评分均有所降低,观察组评分均低于对照组,差异均有统计学意义(P<0.05);对照组治疗有效率为80.00%低于观察组的96.67%,观察组疗效更显著,差异有统计学意义(P<0.05);观察组不良反应发生率为16.67%,对照组为13.33%,差异无统计学意义(P>0.05)。结论:急性轻型脑梗死采用多药物联合治疗,有效改善神经功能,疗效显著,且不增加药物毒副作用,具有临床使用价值。

Objective:To investigate the clinical effects and adverse drug effects of aspirin and clopidogrel in patients with acute mild cerebral infarction.Methods:From January to December 2019,60 cases of patients with acute mild cerebral infarction in a hospital were selected as the research object,and divided into two groups by random number table method.On the basis of routine medical treatment,the control group(n=30)was given aspirin enteric-coated tablets treatment,and the observation group(n=30)was given clopidogrel combined with aspirin enteric coated tablets treatment,then the neurological function,adverse reactions,and the curative effect of the two groups were observed and compared.Results:Before treatment,there was no significant difference in the scores of neurological deficit function in all patients(P>0.05).After treatment,all of the scores were reduced,the scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The effective rate of the control group was 80.00%,which was lower than that of the observation group(96.67%).The effect of the observation group was more significant,the difference was statistically significant(P<0.05).The incidence of adverse reactions was 16.67%in the observation group and 13.33%in the control group,and the difference was not statistically significant(P>0.05).Conclusion:The application of multi-drug combination therapy in the treatment of acute mild cerebral infarction(AMI)can effectively improve neurological function,has significant efficacy,and does not increase drug toxic side effects,which has clinical application value.