长余辉纳米材料的控制合成及在疾病诊断中的应用

Recent Progress in Controlled Synthesis of Persistent Luminescence Nanomaterials for Diagnosis Applications

长余辉纳米材料具有独特的发光性质,能在激发光关闭后持续发光.通过收集激发光关闭后的长余辉发光信号可以有效消除背景信号的干扰.此外,长余辉材料在成像时无需原位激发,可以减少生物体系的组织自发荧光和光散射干扰,提高生物成像和检测的灵敏度.由于这种独特的光学特性,长余辉纳米材料在生物传感/生物成像以及疾病治疗等领域被广泛应用.近年来,为满足疾病相关生物标志物的体外检测及体内生物成像的应用要求,控制合成发光性能优异、生物相容性好的长余辉纳米材料成为研究热点.

Persistent luminescence nanomaterials with special optical characteristics can remain luminescent after cessation of excitation.By collecting the persistent luminescence signal after autofluorescence decays,autofluorescence interference can be efficiently eliminated.Additionally,the interference of light scattering can also be avoided since in situ light excitation is not involved,leading to improved sensitivity in biodetection and bioimaging.Owing to the distinct optical properties,persistent luminescence nanoparticles opened a new door to the biological applications from biosensing/bioimaging to theranostics.Recently,controlled synthesis of persistent luminescence nanomaterials with improved luminescent properties and biocompatibility has attracted great attention with the increasing need for in vitro biodetection and in vivo bioimaging.In this review,we firstly summarize the controlled synthesis method for persistent luminescence nanomaterials,such as sol-gel method,hydrothermal method,thermal decomposition method,template method,etc.Secondly,the application of the persistent luminescence nanomaterials for diagnosis both in vitro and in vivo are further discussed.Given the potential of persistent luminescence nanomaterials in biosensing,the current challenges and future perspective are also discussed.