多孔配位聚合物靶向亚细胞器用于生物成像和诊疗

Coordination Porous Polymers for Targeting Subcellular Organelles:Bio-imaging,Diagnosis and Therapy

由于外界环境和生活习惯的变化,癌症病发率和死亡率日益攀升,因此癌症防治问题亟待解决.近年来报道了多种根据多孔纳米材料性质设计的用于体内肿瘤细胞的靶向药物.金属有机框架(Metal-organic framework, MOF)和多孔配位笼(Porous coordination cage, PCC)由于其结构多样,可设计性强,且具有一定的可修饰性,受到广泛的关注并得到了长足的发展.虽然金属有机框架和多孔配位笼已经在气体吸附分离、手性分离、催化、荧光与传感及导电等领域被广泛研究,但在生物医学方面的应用还未得到充分开发.本文总结了金属有机框架和多孔配位笼在生物体中成像和诊疗应用的研究工作,并且指出了目前配位多孔聚合物在生物医学方面应用中存在的一些问题.

Due to the changes in the external environment and living habits,the incidence and mortality rate of cancer are increasing day by day,so the problem of cancer prevention and treatment needs to be solved urgently.In recent years,a variety of targeted drugs for tumor cells in vivo have been reported based on the properties of porous nanomaterials.Metal-organic framework(MOF)and porous coordination cage(PCC)can be modified to some extent due to their diverse structures,high design ability,and certain modifiability.Therefore,it has received the favor of many researchers and obtained considerable development.Although metalorganic frameworks and porous coordination cages have been extensively studied in the fields of gas adsorption separation,chiral separation,catalysis,fluorescence and sensing,and electrical conductivity,their applications in biomedical applications have not been fully explored.In this paper,the research work of metal-organic framework and porous coordination cage in imaging and diagnosis and treatment of organisms is summarized,and some problems existing in the application of coordinated porous polymers in the biomedical field are pointed out.