核酸适体功能化的二维材料场效应晶体管传感器研究进展

Recent Progress of Aptamer Functionalized Two-dimensional Materials Field Effect Transistor Sensors

二维材料场效应晶体管传感器具有可调的电学性质和高的灵敏度,非常适合用于构建高性能的传感器,应用于疾病诊断和环境监测等领域.核酸适体是一种生物识别分子,具有特异性强、稳定性高等优势.近年来,核酸适体功能化的二维材料场效应晶体管传感器在医疗诊断和环境监测等领域取得了显著的研究进展.本文综合评述了核酸适体功能化的二维材料场效应晶体管传感器的最新研究进展,对场效应晶体管传感器的结构及传感原理进行了概括,详细介绍了二维材料的制备方法以及核酸适体功能化器件的设计原理.在此基础上,对核酸适体功能化的二维材料场效应晶体管传感器在疾病诊断和环境监测领域的应用进展进行了概述,讨论了核酸适体功能化的二维材料场效应晶体管传感器面临的一些问题和挑战,对其发展前景进行了展望.

Two-dimensional materials field-effect transistor sensors with adjustable electrical properties have been viewed as potential candidates for the design of high performance sensors for disease diagnosis and environmental monitoring.As a kind of nucleic acid molecules with recognition capability,aptamer exhibits high specificity and excellent stability for target molecules.In recent years,remarkable progress has been achieved in the field of aptamer functionalized two-dimensional materials field-effect transistor sensors.In this review,the latest research progress of aptamer functionalized two-dimensional materials field-effect transistor sensors is summarized.The structure and sensing principle of field-effect transistor sensors are illustrated.The preparation methods of two-dimensional materials and the design principle of aptamer functionalized sensors are comprehensively reviewed.For a further step,the application of aptamer functionalized two-dimensional materials field-effect transistor sensors in the field of disease diagnosis and environmental monitoring is summarized.Finally,the challenges and prospects of aptamer functionalized two-dimensional materials field-effect transistor sensors are discussed.