基于分子识别的细菌检测研究进展

Advances in Bacteria Biosensing Based on Molecular Recognition

以抗体-抗原免疫识别、核酸碱基互补配对识别以及核酸适体-配体识别这3种分子识别方式分类,综述了近几年基于分子识别的细菌检测研究工作进展,总结了细菌检测相关研究存在的一些挑战,并展望了该领域的发展前景.

Bacteria widely exist in the natural environment and are closely related to human health.The identification and detection of bacteria are of great significance for public health and medical health.Recently,more attention has been attracted in molecular recognition-based bacteria biosensing with high specificity and sensitivity.Herein,recent progresses of bacterial detection based on molecular recognition are reviewed.Molecular recognition methods are classified into three kinds of interactions:antibody-antigen immune interaction,nucleic acid recognition based on Watson-Crick base-pairing,and aptamer-ligand interaction.Finally,the existing bottlenecks of bacterial detection related research are summarized,and the potential of this field is inspiring.