新疆地区不同年龄居民中睡眠时长与糖尿病的相关性

Correlation between sleep duration and incident diabetes among residents of different ages in Xinjiang region

目的探讨在40岁以上的新疆克拉玛依社区人群中,睡眠时长与糖尿病患病风险的相关性。方法采取整群抽样的方法,对新疆克拉玛依地区9541名40岁以上常驻居民进行标准化问卷调查、体格检查、生化指标监测等。根据每日总体睡眠时长将人群分为3组:睡眠时长不足(每日总体睡眠时长<6 h)、理想睡眠时长(6~8 h)及长时间睡眠(>8 h)。并进一步根据年龄分层,年龄<60岁者被定义为中年组,余下为老年组。利用多元logistic回归分析模型探究2组不同年龄的研究对象睡眠时长与糖尿病患病风险的相关性。结果睡眠时长与空腹血糖、HbA_(1C)水平之间呈现近似U型关系,理想睡眠时长下的空腹血糖和HbA1C水平最低。经多因素校正之后,总体人群中,与理想睡眠时长者相比,睡眠不足者的糖尿病患病风险增加35%(OR=1.35,95%CI 1.06~1.71),而长时间睡眠者的患病风险未显著增加(OR=1.04,95%CI 0.94~1.14)。在进一步按照年龄分层后,仅在中年组(40~60岁)中观察到睡眠时长不足与糖尿病患病风险的增加显著相关(OR=1.37,95%CI 1.02~1.84)。结论在新疆克拉玛依地区不同年龄居民中,睡眠不足者与糖尿病患病风险增加存在相关性,并且这种差异仅在40~60岁的中年人群中显著。

Objective To explore the correlation between sleep duration and incident diabetes among residents of different ages in Xinjiang region.Methods A total of 9541 residents,aged 40 and over in Karamay,Xinjiang were identified by a cluster sampling method.Physical examinations and biochemical test were performed,and the data on sleep duration and lifestyle were obtained using standardized questionnaires.The population was divided into three categories according to sleep duration:insufficient sleep(<6 h),ideal sleep(6-8 h),and long sleep duration(>8 h).They were further divided into 2 subgroups based on age at survey.Those who were younger than 60 years old were defined as the middle-aged group,and the rest as the elderly.Multivariate logistic regression analysis was used to explore the correlation between sleep duration and the risk of diabetes in different age groups.Results There existed an approximate U-shaped relationship between total sleep duration and fasting blood glucose as well as HbA1C.Fasting blood glucose and HbA1C were relatively lower among those with ideal sleep duration.After multivariable adjustment,residents with insufficient sleep revealed a 35%increased risk of diabetes(OR=1.35,95%CI 1.06-1.71)compared with those with ideal sleep duration.However,the risk of diabetes was not significantly increased in those with long sleep duration(OR=1.04,95%CI 0.94-1.14).Furthermore,the additive risk of insufficient sleep was only significant in the middle-aged group(OR=1.37,95%CI 1.02-1.84).Conclusions Among residents of different ages in Xinjiang region,insufficient sleep is associated with an increased risk of diabetes,which is only significant in the middle-aged group.