摘要
目的研究茯神Poria cocos(Schw.)Wolf的化学成分。方法茯神75%乙醇提取物采用硅胶、Sephadex LH-20及HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到12个化合物,分别鉴定为8-羟基松脂醇(1)、松脂醇(2)、白桦脂醇(3)、白桦脂酸(4)、3-羰基齐墩果酸(5)、脱氢山楂酸(6)、泽泻醇C-23-醋酸酯(7)、 2α,19α-二羟基熊果酸(8)、乌索酸(9)、熊果酸(10)、土莫酸(11)、茯苓酸(12)。结论化合物1~8为首次从该植物中分离得到。
AIM To study the chemical constituents from Poria cocos(Schw.)Wolf.METHODS The 75% ethanol extract from P. cocos was isolated and purified by silica, Sephadex LH-20 and semi-preparative HPLC, then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twelve compounds were isolated and identified as 8-hydroxypinoresinol(1),pinoresinol(2),betulin(3),betulinic acid(4),3-oxo-oleanolic acid(5),camaldulenic acid(6),23-acetate alisol C(7),2α,19α-dicarboxyl ursolic acid(8),ursonic acid(9),ursolic acid(10),tumulosic acid(11),pachymic acid(12).CONCLUSION Compounds 1-8 are isolated from this plant for the first time.
作者
王军民
刘思远
杨莹
王涛
张红霞
WANG Jun-min;LIU Si-yuan;YANG Ying;WANG Tao;ZHANG Hong-xia(Ministry of Education Key Laboratory for Forest Resources Conservation and Utilization in Southwest Mountainous,Southwest Forestry University,Kunming 650224,China;Key Laboratory for Economic Plants and Biotechnology,Yunnan Provincial Key Laboratory far Research and Development of Wild Plant Resources,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650223,China)
出处
《中成药》
CAS
CSCD
北大核心
2021年第10期2728-2732,共5页
Chinese Traditional Patent Medicine
基金
农业联合面上项目[2017FG001(-047)]。
关键词
茯神
化学成分
分离鉴定
Poria cocos(Schw.)Wolf
chemical constituents
isolation and identification