茯神化学成分的研究

Chemical constituents from Poria cocos

目的研究茯神Poria cocos(Schw.)Wolf的化学成分。方法茯神75%乙醇提取物采用硅胶、Sephadex LH-20及HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到12个化合物,分别鉴定为8-羟基松脂醇(1)、松脂醇(2)、白桦脂醇(3)、白桦脂酸(4)、3-羰基齐墩果酸(5)、脱氢山楂酸(6)、泽泻醇C-23-醋酸酯(7)、 2α,19α-二羟基熊果酸(8)、乌索酸(9)、熊果酸(10)、土莫酸(11)、茯苓酸(12)。结论化合物1~8为首次从该植物中分离得到。

AIM To study the chemical constituents from Poria cocos(Schw.)Wolf.METHODS The 75% ethanol extract from P. cocos was isolated and purified by silica, Sephadex LH-20 and semi-preparative HPLC, then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twelve compounds were isolated and identified as 8-hydroxypinoresinol(1),pinoresinol(2),betulin(3),betulinic acid(4),3-oxo-oleanolic acid(5),camaldulenic acid(6),23-acetate alisol C(7),2α,19α-dicarboxyl ursolic acid(8),ursonic acid(9),ursolic acid(10),tumulosic acid(11),pachymic acid(12).CONCLUSION Compounds 1-8 are isolated from this plant for the first time.