美托洛尔与尼卡地平用于急诊主动脉夹层患者治疗中的临床效果

Clinical effect of metoprolol and nicardipine in the treatment of emergency aortic dissection

目的:探讨美托洛尔联合尼卡地平治疗急诊主动脉夹层患者的临床效果。方法:将68例急诊主动脉夹层患者根据入院时间分为观察组(n=34)与对照组(n=34)。对照组采用美托洛尔治疗,观察组采用美托洛尔联合尼卡地平治疗,对比两组临床治疗效果,治疗后0.5 h、1 h和3 h的心率、血压及其达标率、不良反应发生情况。结果:观察组临床治疗效果显著优于对照组,不良反应发生率明显低于对照组;观察组治疗后0.5 h、1 h和3 h的心率、收缩压及舒张压均明显低于对照组,且达标率均明显高于对照组(均P<0.05)。结论:临床上对急诊主动脉夹层患者采用美托洛尔联合尼卡地平治疗疗效显著,安全性高,可有效控制患者心率与血压。

Objective:To investigate the clinical effect of metoprolol combined with nicardipine in the treatment of emergency aortic dissection.Methods:Sixty-eight patients with emergency aortic dissection were divided into an observation group(n=34)and a control group(n=34)based on admission time.The control group was treated with metoprolol,while the observation group with both metoprolol and nicardipine.The clinical therapeutic effects were compared between the two groups.The clinical efficacy,the heart rate at 0.5 h,1 h and 3 h after treatment,the blood pressure,the rate of reaching the standard and the incidence of adverse reactions were compared between the two groups.Results:The clinical therapeutic effect was significantly better,the incidence of adverse reactions was significantly lower,the heart rate,systolic and diastolic blood pressure at 0.5 h,1 h and 3 h after treatment were significantly lower and the rate of reaching the standard was significantly higher in the observation group than the control group(all P<0.05).Conclusion:Metoprolol combined with nicardipine is effective and safe in the treatment of emergency aortic dissection.