赫赛汀联合化疗治疗41例晚期乳腺癌患者的效果分析

Effect of Herceptin combined with chemotherapy in the treatment of patients with advanced breast cancer

目的:探讨靶向药物赫赛汀联合化疗治疗晚期乳腺癌的效果。方法:将82例晚期乳腺癌患者随机分为两组研究组(n=41)与对照组(n=41)。两组均给予化疗治疗,研究组再给予靶向药物赫赛汀,比较两组治疗效果及不良反应情况。结果:研究组IL-2、IL-6、IL-10、TNF-α、CRP、CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)均显著优于对照组,不良反应总发生率显著低于对照组(均P<0.05)。结论:靶向药物赫赛汀联合化疗治疗晚期乳腺癌的效果显著,有利于改善炎症因子水平,调节免疫功能,减少不良反应发生率。

Objective:To investigate the efficacy of Herceptin combined with chemotherapy in the treatment of advanced breast cancer.Methods:Eighty-two patients with advanced breast cancer were randomly divided into a study group(n=41)and a control group(n=41).Both groups were treated with chemotherapy and the study group was additionally treated with a targeted drug Herceptin.The therapeutic effects and adverse reactions were compared between the two groups.Results:IL-2,IL-6,IL-10,TNF-α,CRP,CD_(3)^(+),CD_(4)^(+),CD_(8)^(+) and CD_(4)^(+)/CD_(8)^(+) were significantly better and the overall incidence of adverse reactions was significantly lower in the study group than the control group(all P<0.05).Conclusion:Herceptin combined with chemotherapy is effective in the treatment of advanced breast cancer and can improve the level of inflammatory factors,regulate the immune function and reduce the incidence of adverse reactions.