人溶瘤腺病毒的研究进展

Research progress of human oncolytic adenovirus

溶瘤腺病毒是一种经过人工改造的,可以特异性杀伤肿瘤细胞的一类腺病毒。常用的腺病毒为致病力弱的人血清2型或5型腺病毒。该病毒对正常机体的细胞无明显不良反应,但是可以特异性地在肿瘤细胞中大量增殖、裂解肿瘤细胞和破坏肿瘤微环境。在溶瘤腺病毒的作用下被感染的肿瘤细胞释放出大量的肿瘤特异性抗原,进而激发全身性的抗肿瘤免疫反应,最终达到治疗肿瘤的目的。溶瘤腺病毒治疗肿瘤不良反应小、精度高、抗干扰能力强,具有广阔的运用前景。

Oncolytic adenovirus is a type of human adenovirus that is artificially modified and can specifically kill tumor cells.Commonly used adenovirus is human adenovirus serotype 2 or serotype 5,both are weakly pathogenic adenoviruses.This virus has no obvious adverse reactions to normal body cells,however,it can specifically proliferate in tumor cells in large quantities and lyse tumor cells and destroy the tumor microenvironment.Under the action of oncolytic adenovirus,the infected tumor cells release a large number of tumor-specific antigens,which ultimately stimulate a systemic anti-tumor immune response,and finally achieve the purpose of treating tumors.Oncolytic adenovirus for the treatment of tumors has small adverse reactions,high precision and strong anti-interference abilities and may have broad application prospects.