沙库巴曲缬沙坦治疗急性心肌梗死合并心力衰竭患者的效果

Effects of Sacubitril and Valsartan in treatment of patients with acute myocardial infarction and heart failure

目的:观察沙库巴曲缬沙坦治疗急性心肌梗死合并心力衰竭患者的效果。方法:回顾性分析2020年1—3月该院收治的79例急性心肌梗死合并心力衰竭患者的临床资料,按照治疗方法分为对照组42例和观察组37例。对照组采取常规治疗,观察组在对照组的基础上联合沙库巴曲缬沙坦治疗,比较两组临床疗效,治疗前后血管内皮细胞黏附分子-1(VCAM-1)水平、可溶性细胞间黏附分子-1(ICAM-1)水平、心功能指标[左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)]水平,以及不良反应发生率。结果:观察组治疗总有效率为97.3%,高于对照组的78.6%,差异有统计学意义(P<0.05);治疗后,观察组VCAM-1和ICAM-1水平均低于对照组,差异有统计学意义(P<0.05);观察组LVESD和LVEDD水平均低于对照组,LVEF水平高于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为5.4%,低于对照组的21.4%,差异有统计学意义(P<0.05)。结论:在常规治疗基础上,采用沙库巴曲缬沙坦治疗急性心肌梗死合并心力衰竭患者,可提高治疗总有效率,降低LVESD水平、LVEDD水平和不良反应发生率,改善心功能指标水平,其效果优于单纯常规治疗。

Objective:To observe effects of Sacubitril and Valsartan in treatment of patients with acute myocardial infarction and heart failure.Methods:A retrospective analysis of the clinical data of 79 patients with acute myocardial infarction and heart failure admitted to the hospital from January to March 2020 was performed.According to the treatment method,they were divided into control group(42 cases)and observation group(37 cases).The control group took conventional treatment,while the observation group was given with Sacubitril and Valsartan on the basis of that of the control group.The clinical efficacy,the vascular endothelial cell adhesion molecule-1(VCAM-1)level,the soluble intercellular adhesion molecule-1(ICAM-1)level,the heart function index[left ventricular end systolic diameter(LVESD),left Ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)]levels,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 97.3%,which was higher than 78.6%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of VCAM-1 and ICAM-1 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The LVESD level and LVEDD level of the observation group were lower than those of the control group;the LVEF level was higher than that of the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 5.4%,which was significantly lower than 21.4%in the control group,and the difference was statistically significant(P<0.05).Conclusions:On the basis of the conventional treatment,Sacubitril and Valsartan in the treatment of the patients with acute myocardial infarction and heart failure can increase the total effective rate of treatment,reduce the LVESD level,the LVEDD level and the incidence of adverse reactions,and improve the heart function index levels.Moreover,it is superior to single conventional treatment.