内镜介入联合质子泵抑制剂三联疗法治疗消化性溃疡合并上消化道出血患者的效果

Effects of endoscopic interventional therapy combined with proton pump inhibitor triple therapy in treatment of patients with peptic ulcer and upper gastrointestinal hemorrhage

目的:观察内镜介入联合质子泵抑制剂三联疗法治疗消化性溃疡合并上消化道出血患者的效果。方法:选取80例消化性溃疡合并上消化道出血患者作为研究对象,按照随机数字表法分为对照组和观察组各40例。两组均行补液、吸氧和止血等基础处理,在此基础上,对照组予以质子泵抑制剂三联疗法治疗,观察组在对照组基础上联合内镜介入治疗,比较两组临床疗效,皮质醇(Cor)、肿瘤坏死因子-α(TNF-α)和C反应蛋白(CRP)水平,以及不良反应/并发症发生率。结果:观察组治疗总有效率为95.00%,明显高于对照组的77.50%,差异有统计学意义(P<0.05);治疗后,观察组Cor、TNF-α和CRP水平均低于对照组,差异有统计学意义(P<0.05);观察组不良反应/并发症发生率为2.50%,明显低于对照组的20.00%,差异有统计学意义(P<0.05)。结论:内镜介入联合质子泵抑制剂三联疗法治疗消化性溃疡合并上消化道出血患者可提高治疗总有效率,降低Cor、TNF-α、CRP水平和不良反应/并发症发生率,其效果优于单纯质子泵抑制剂三联疗法治疗。

Objective:To observe effects of endoscopic interventional therapy combined with proton pump inhibitor triple therapy in treatment of patients with peptic ulcer and upper gastrointestinal hemorrhage.Methods:80 patients with peptic ulcer and upper gastrointestinal hemorrhage were selected as the research objects,and were divided into control group and observation group according to the random number table method,each with 40 cases.Both groups were given basic treatments such as fluid infusion,oxygen inhalation and hemostatic drugs.On this basis,the control group was treated with proton pump inhibitor triple therapy,while the observation group was combined with endoscopic interventional therapy on the basis of that of the control group.The clinical efficacy,the levels of cortisol(Cor),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP),and the incidence of adverse reactions/complications were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.00%,which was significantly higher than 77.50%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of Cor,TNF-αand CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions/complications in the observation group was 2.50%,which was significantly lower than 20.00%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Endoscopic interventional therapy combined with proton pump inhibitor triple therapy in treatment of patients with peptic ulcer and upper gastrointestinal hemorrhage can improve the total effective rate of treatment,and reduce the levels of Cor,TNF-α,CRP and the incidence of adverse reactions/complications.Moreover,it is superior to single proton pump inhibitor triple therapy.