南充地区体检者空腹血糖受损的检出情况及相关危险因素筛查

Detection of impaired fasting blood glucose and screening of related risk factors in physical examinations in Nanchong area

目的研究南充地区体检人群空腹血糖受损的检出情况及其影响因素。方法对2018年1月至2020年1月南充地区川北医学院附属医院健康管理中心开展体检及空腹血糖检测的体检者27585例进行前瞻性队列研究。其中,男15284例(55.4%),女12301例(44.6%)。获取所有体检者体重指数(BMI)、血压(收缩压、舒张压)、空腹血糖、血脂(三酰甘油、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)、血尿酸、同型半胱氨酸、超敏促甲状腺激素相关体格检查和生化指标。按血糖高低分为空腹血糖正常组(3.85~6.11 mmol/L)、空腹血糖受损组(>6.11~<7.00 mmol/L)、糖尿病组(≥7.0 mmol/L)。分析空腹血糖与相关体格检查及生化指标的相关性。结果空腹血糖受损检出率为4.09%,糖尿病检出率为5.17%。3组间年龄、BMI、收缩压、舒张压、尿酸、三酰甘油、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、同型半胱氨酸、总胆红素等比较,差异均有统计学意义(P<0.05)。而3组间超敏促甲状腺激素比较差异无统计学意义(P>0.05)。多因素logistic回归分析显示,年龄、男性、BMI、收缩压、舒张压、三酰甘油、低密度脂蛋白胆固醇为空腹血糖调节受损的独立危险因素。结论早期筛查出空腹血糖受损相关因素并进行早期健康干预,对预防及延缓糖尿病的发生、发展具有重要意义。

Objective To explore the detection of impaired fasting blood glucose and its influencing factors in the physical examination population in Nanchong.Methods A prospective cohort study was conducted on 27585 people who underwent a physical examination and fasting blood glucose test at the Health Management Center of the Affiliated Hospital of North Sichuan Medical College in Nanchong from January 2018 to January 2020.Among them,15284(55.4%)were males and 12301(44.6%)were females.BMI,blood pressure(systolic blood pressure,diastolic blood pressure),fasting blood glucose,blood lipids(triglycerides,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol),blood uric acid,homocysteine,and hypersensitivity thyroid stimulating hormone related physical examination and biochemical indicators were obtained for all physical examination subjects.According to the level of blood sugar,they were divided into groups:normal fasting blood glucose group(3.85-6.11 mmol/L),impaired fasting blood glucose group(>6.11-<7.00 mmol/L),and diabetes group(≥7.0 mmol/L).The correlation between fasting blood glucose and related physical examination and biochemical indicators of physical examiners was analyzed.Results The detection rate of impaired fasting blood glucose was 4.09%,and the detection rate of diabetes was 5.17%.Comparison of age,body mass index,systolic blood pressure,diastolic blood pressure,uric acid,triacylglycerol,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,homocysteine and total bilirubin among the three groups showed statistically significant differences(P<0.05).However,there was no significant difference in hypersensitivity thyroid stimulating hormone among the 3 groups(P>0.05).Multivariate logistic regression analysis showed that age,male,BMI,systolic blood pressure,diastolic blood pressure,triacylglycerol,and low-density lipoprotein cholesterol were independent risk factors for impaired fasting blood glucose regulation.Conclusion Early screening of factors related to impaired fasting blood glucose and early health intervention are of great significance for preventing and delaying the occurrence and development of diabetes.