光催化氧化合成2-氟-3-硝基苯甲酸的研究

Synthesis of 2-Fluoro-3-nitrobenzoic Acid through Photocatalytic Oxidation

以2-氟-3-硝基甲苯为原料、醋酸为溶剂、硫酸铜和氢溴酸为催化剂,经光催化氧化合成新型杀虫剂溴虫氟苯双酰胺和环丙氟虫胺的关键中间体2-氟-3-硝基苯甲酸。含量98%,收率90.0%,反应条件温和,工艺环保,具有较高的应用价值。

2-Fluoro-3-nitrobenzoic acid is a key intermediate of Broflanilide and Cyproflanilide.2-Fluoro-3-nitrobenzpic acid was synthesized by photocatalytic oxidation using 2-fluoro-3-nitroluene as the raw material,acetic acid as the solvent,cupric sulfate and hydrobromic acid as catalysts.A reaction yield of 90%with a purity of 98%was obtained.The condition of this reaction is mild;and the process is environmental-friendly;so,it has high value for industrial application.