2型糖尿病VEGF、Alb及HbA1c与肾脏微小血管病变的关系

Relationship between the levels of VEGF,Alb and HbA1c and renal microangiopathy in patients with type 2 diabetes

目的研究2型糖尿病血管内皮生长因子(VEGF)、尿白蛋白及糖化血红蛋白与肾脏微小血管病变的关系。方法选取2019年1月至2020年6月本院收治的160例2型糖尿病患者作为研究组,另选取155例同期于本院进行健康体检且检查结果正常者作为对照组。比较两组VEGF、尿白蛋白及糖化血红蛋白的表达水平,计算研究组合并肾脏微小血管病变发生率,采用多元Logistic回归分析影响糖尿病患者并发肾脏微小血管病变的危险因素。结果研究组VEGF、尿白蛋白及糖化血红蛋白水平均高于对照组,差异均有统计学意义(P<0.05)。2型糖尿病合并肾脏微小血管病变患者53例(33.12%),归为合并组,未合并肾脏微小血管病变患者107例(66.88%),归为未合并组。合并组VEGF、尿白蛋白及糖化血红蛋白水平均高于未合并组,差异均有统计学意义(P<0.05)。吸烟、LDL-C、FPG、VEGF、尿白蛋白及糖化血红蛋白为糖尿病并发肾脏微小血管病变的单因素(P<0.05)。FPG、VEGF、尿白蛋白及糖化血红蛋白水平异常为影响糖尿病并发肾脏微小血管病变的独立危险因素(P<0.05)。结论VEGF、尿白蛋白及糖化血红蛋白水平在2型糖尿病合并肾脏微小血管病变中呈异常表达,监测三者有助于患者病情变化的评估。

Objective To study the relationship between the levels of vascula endothelial growth factor(VEGF),urinary albumin and glycosylated hemoglobin and renal microvascular disease in patients with type 2 diabetes.Methods The 160 patients with type 2 diabetes who were admitted to the hospital from January 2019 to June 2020 were selected as the study group.In addition,155 patients who had physical examination in this hospital during the same period and had normal results were selected as the control group.The expression levels of VEGF,urinary albumin and glycosylated hemoglobin between two groups were compared.The incidence of renal microvascular disease in the study group was calculated,and multivariate logistic regression was used to analyze the risk factors of renal microvascular disease in diabetic patients.Results The levels of VEGF,urinary albumin and glycosylated hemoglobin in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).53 cases(33.12%)with type 2 diabetes combined with renal microvascular disease were classified as the combined group,and 107 cases(66.88%)without renal microvascular disease were classified as the non-combined group.The levels of urinary albumin and glycosylated hemoglobin in the combined group were higher than those in the non-combined group,and the differences were statistically significant(P<0.05).Smoking,LDL-C,FPG,VEGF,urinary albumin and glycosylated hemoglobin were the single factors affecting diabetes complicated with renal microvascular disease(P<0.05).Abnormal levels of FPG,VEGF,urinary albumin and glycosylated hemoglobin were independent risk factors affecting diabetes complicated with renal microvascular disease(P<0.05).Conclusion The levels of VEGF,urinary albumin and glycosylated hemoglobin are abnormally expressed in patients with type 2 diabetes and renal microvascular disease.Monitoring the three is helpful for the evaluation of the patient’s condition changes.