摘要
在表观遗传修饰方面,与DNA甲基化修饰类似,RNA甲基化修饰为一个很有潜力的研究方向。作为最常见的RNA甲基化修饰形式,m6A修饰在许多疾病特别是肿瘤中发挥着重要作用。m6A由甲基转移酶催化,去甲基酶去除,并与m6A结合蛋白相互作用。本综述在现有研究的基础上,对m6A修饰在泌尿系肿瘤中可能存在的调控网络进行描述,着重讨论m6A修饰相关的调控分子作为泌尿系肿瘤治疗、诊断及预后的新靶点,以期为探索泌尿系肿瘤的发病机制提供新的方向,并为开发有效的泌尿系肿瘤治疗方案提供策略。
In epigenetic modification,similar to DNA methylation,RNA methylation is a potential research direction.As the most common form of RNA methylation,N6-methyladenosine(m6A)methylation plays an important role in many diseases,especially in tumors.m6A is catalyzed by methyltransferase,removed by demethylase and interacts with m6A-binding proteins.Based on the existing research,this review describes the possible regulatory network of m6A methylation in urological cancers,and focuses on the regulatory molecules related to m6A modification as a new target for the treatment,diagnosis and prognosis of urological cancers,providing a new direction for exploring the pathogenesis of urinary tract tumors.
作者
李金珂
袁焰
LI Jinke;YUAN Yan(Department of Organ Transplantation,Renmin Hospital of Wuhan University,Hubei,Wuhan,China,430060)
出处
《分子诊断与治疗杂志》
2021年第10期1726-1730,共5页
Journal of Molecular Diagnostics and Therapy
基金
国家自然科学基金(81972408)
武汉市应用基础前沿项目(2018060401011321)。
