肿瘤恶病质血液分子标志物的研究进展

Research progression in blood biomarkers of cancer cachexia

肿瘤恶病质是一种多因素复杂综合征,多表现为体重减轻、厌食、肌肉萎缩和营养状况恶化,>20%的肿瘤患者死于恶病质。目前,临床实践中恶病质的诊断、分期及监测的过程较为复杂。因此,亟需探索有效、易获取、无创的恶病质分子标志物,来反映患者恶病质的状况,并在恶病质早期诊断、分期、病情监测及治疗疗效评估中能够发挥重要的作用。因此,本文将从恶病质潜在的血液分子生物标志物方面的研究进展进行综述。

Cancer cachexia is a cancer-related multifactorial complex syndrome,characterized byweight loss,anorexia,muscle atrophy and deterioration of nutritional status,contributes to over 20%of all cancer-related death.Cachexiacan be intervened in earlystage,but it is hard to reversein refractory cachexia stages.Thediagnosis of cachexia is of great challenges.At present,effective and suitable biomarkers for detecting cachexiaare extremely lacking in clinical practice.Therefore,this reviewis to describe the present knowledge about the research progression in potential blood biomarkers of cachexia.