某院120例生化药品不良反应报告分析

Analysis of 120 Adverse Drug Reaction Reports of Biochemical Drugs in a Hospital

目的监测医疗机构生化药品不良反应发生特征,为临床安全用药提供参考。方法采用回顾性调查方法,收集某院2014年至2020年上报的120份生化药品不良反应报告,统计并分析患者的性别、年龄、给药途径、药品种类、累及器官/系统、临床表现、临床转归及关联性评价等。结果 120份药品不良反应报告中,50岁以上中老年人为易发人群;静脉给药为发生药品不良反应的主要给药途径;累及器官/系统主要为全身性损害,共55例次(26.70%),其次为皮肤及其附件损害48例次(23.30%);不良反应发生率最高的药品种类为多肽蛋白类,共66例(55.00%),其次为多糖及脂类17例(14.17%),再次为氨基酸及其衍生物15例(12.50%)。结论临床使用生化药品过程中应加强用药监护,减少药品不良反应的发生。

Objective To monitor the characteristics of biochemical adverse drug reactions(ADRs)in medical institutions,and to provide a reference for the safety of drug in the clinic.Methods A total of 120 biochemical ADR reports reported by a hospital from 2014 to2020 were analyzed by retrospective investigation method,inculding the patient’s gender,age,route of administration,drug type,involved organ/system,clinical manifestation,clinical outcome and relevance evaluation.Results Among 120 ADR reports,middle-aged and elderly people over 50 years old were high-risk population occurred ADRs.Intravenous administration was the main route that led to ADRs.The main organ/system involved in ADRs was systemic damage(55 cases,26.70%),followed by skin and its appendages damage(48 cases,23.30%).The highest incidence of adverse reactions was caused by polypeptide proteins(66 cases,55.00%),followed by polysaccharides and lipids(17 cases,14.17%),amino acids and their derivatives(15 cases,12.50%).Conclusion The clinical monitoring of biochemical drugs should be strengthened to reduce the occurrence of ADRs.