预后营养指数预测口腔鳞状细胞癌患者预后的效果分析

Efficacy of prognostic nutritional index for predicting prognosis of patients with oral squamous cell carcinoma

目的探讨术前采用预后营养指数(PNI)预测口腔鳞状细胞癌(OSCC)患者预后的临床效果。方法选取2019年1月至2021年2月间陕西中医药大学第二附属医院收治的60例OSCC患者,整理患者基础资料和检测血清学指标,分析术前PNI与其他指标的相关性及对患者预后的预测价值。结果相关性分析显示,患者年龄、吸烟、酗酒、原发肿瘤直径、分化程度、预后营养指数和淋巴细胞-单核细胞比值与PNI均存在相关性(均P<0.05)。单因素分析结果显示,患者年龄、原发肿瘤直径、分化程度、体质量指数(BMI)、酗酒、复发、血小板-淋巴细胞比值及PNI是影响生存时间的影响因素(均P<0.05)。多因素分析结果显示,BMI、酗酒、复发及PNI是影响患者生存时间的危险因素(均P<0.05)。结论OSCC患者生存危险因素包括BMI、酗酒、复发及PNI;PNI与患者一般资料具有相关性,在患者预后预测中价值较高,可为后续治疗及康复提供一定的临床支持。

Objective To explore and analyze the clinical efficacy of preoperative prognostic nutri-tional index(PNI)for predicting the prognosis of patients with oral squamous cell carcinoma.Methods In this study,60 patients with oral squamous cell carcinoma admitted to The Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine were selected from January 2019 to February 2021.The general information was collected and sorted and serum indexes were tested.The correlation between preop-erative PNI and other indicators,and the significance for the prognosis of the patient.Results The results of the correlation analysis showed that PNI was associated with age,smoking,alcoholism,primary tumor size,and degree of differentiation,neutrophil-to-lymphocyte ratio(NLR),and lymphocyte-to-monocyte ra-tio(LMR)(all P<0.05).The results of univariate analysis showed that the factors influencing survival included age,primary tumor size,degree of differentiation,PLR,and PNI(all P<0.05).The results of multivariate analysis showed treatment methods,tumor size,recurrence and PNI were the risk factors influ-encing survival(all P<0.05).Conclusion Treatment methods,tumor size,recurrence and PNI were risk factors influencing survival in patients with oral squamous cell carcinoma.PNI is associated with general patient information,and has significant value for predicting the prognosis,and can provide a certain support for subsequent treatment and rehabilitation.