益肾化痰法治疗非酒精性脂肪性肝病的疗效观察及对RBP-4、SREBP-1C的影响

Observation on Curative Effect of NAFLD Treated with Tonifying Kidney and Removing Phlegm Therapy and Effects on Serum RBP-4,SREBP-1C

目的:观察益肾化痰法治疗非酒精性脂肪性肝病(NAFLD)的临床疗效及其对肝功、血脂、视黄醇结合蛋白-4(RBP-4)、固醇调节元件结合蛋白-1C(SREBP-1C)的影响。方法:NAFLD患者135例,随机分为益肾化痰法治疗组(67例)和复方二氯醋酸二异丙胺片治疗对照组(68例),治疗2个月后;观察2组患者的肝功能指标谷丙转氨酶(ALT)、谷草转氨酶(AST)和血脂指标三酰甘油(TG)、总胆固醇(TC)变化,检测细胞因子RBP-4以及SREBP-1C,超声检查肝、脾CT值,比较两组患者的治疗效果。结果:治疗组与对照组患者在治疗2个月后,ALT、AST、TC、TG、RBP-4和SREBP-1C均降低(P<0.05);治疗组较对照组的RBP-4、SREBP-1C下降更为明显(P<0.05)。两组治疗后肝、脾CT值与治疗前相比均有所改善(P<0.05),两组之间在治疗后肝、脾CT值相比,无统计学意义(P>0.05)。治疗组予益肾化痰法治疗NAFLD的临床疗效优于对照组(P<0.05)。结论:益肾化痰法治疗NAFLD,能够在一定程度上改善肝功能,调整血脂水平,降低RBP4、SREBP-1C的水平。

Objective:To observe the curative effect of nonalcoholic fatty liver disease(NAFLD)treated with Tonifying Kidney and Removing Phlegm Therapy and the effects on serum RBP-4,SREBP-1C.Methods:135 Cases with NAFLD were divided into Tonifying Kidney and Removing Phlegm Therapy(treatment group,67 cases)and Diisopropylamine dichloroacetate(control group,68 cases),they were treated for 2 months.ALT,AST,TG and TC of the two groups patients were determined before and after treatment,serum cytokines RBP-4,SREBP-1C were determined by ELISA,CT value of liver and spleen was examined by ultrasound scan,the curative effect was evaluated.Results:After treatment for 2 months,ALT,AST,TG,TC,RBP-4,SREBP-1C of the two groups patients were decreased(P<0.05),the RBP-4,SREBP-1C in treatment group were significantly lower than those in control group(P<0.05).CT value of liver and spleen in the two groups were improved after treatment,there were no significant differences between the two groups(P>0.05).The curative effect of treatment group was better than that of control group(P<0.05).Conclusion:Tonifying Kidney and Removing Phlegm Therapy treat NAFLD,that can improve liver function to a certain extent,regulate blood lipid level,reduce RBP-4,SREBP-1C.