七氟烷和丙泊酚麻醉对老年肺癌患者术后认知功能的影响研究

Analysis of effect of sevoflurane and propofol anesthesia on postoperative cognitive function in elderly patients with lung cancer

目的探究不同麻醉药物在老年肺癌术中的应用及对认知功能的作用机制。方法选取2018年1月至2020年6月于本院行肺癌手术治疗的103例老年患者作为研究对象,根据奇偶法分为Q组(n=52)和B组(n=51),分别予以七氟烷、丙泊酚维持麻醉。观察比较两组麻醉效果及术后认知功能。结果Q组麻醉成功率为96.15%,与B组的94.12%比较差异无统计学意义。术后12、24、72 h,Q组简易智能精神状态评分(MMSE评分)均高于B组(P<0.05);且Q组认知功能障碍(POCD)发生率为51.92%,低于B组的72.55%(P<0.05)。结论七氟烷与丙泊酚在老年肺癌手术中的麻醉效果相当,但七氟烷对患者认知功能的负性影响较小,可作为优选麻醉药物。

Objective To explore the effects of different anesthetics on cognitive function in elderly patients with lung cancer.Methods 103 elderly patients who underwent lung cancer surgery in our hospital from January 2018 to June 2020 were selected as study subjects and they were divided into group Q(n=52)and group B(n=51),and they were given sevoflurane and propofol to maintain anesthesia,respectively.Observe and compare the effects of anesthesia and postoperative cognitive function between the two groups.Results The success rate of anesthesia in group Q was 96.15%,compared with 94.12%in group B,the difference was not statistically significant.At 12 h,24 h and 72 h after operation,MMSE score in group Q was higher than that in group B(P<0.05),and the incidence of cognitive dysfunction(POCD)in group Q was 51.92%,which was lower than 72.55%in group B(P<0.05).Conclusion The anesthetic effects of sevoflurane and propofol are similar in elderly lung cancer surgery,but sevoflurane has less negative effect on cognitive function than propofol,so sevoflurane can be used as the preferred anesthetic.