经鼻持续气道正压通气联合氨溴索对NRDS患儿氧合指标及NCPAP参数的影响

Effects of nasal continuous positive airway pressure combined with ambroxol on oxygenation indexes and NCPAP parameters in children with NRDS

目的探讨经鼻持续气道正压通气(NCPAP)联合氨溴索对新生儿呼吸窘迫综合征(NRDS)患儿氧合指标及NCPAP参数的影响。方法选取2017年2月至2019年12月本院收治的80例NRDS患儿为研究对象,按照随机数表法分为观察组和对照组,每组40例。对照组单独使用NCPAP治疗,观察组使用NCPAP联合氨溴索治疗。比较两组治疗前后氧合指标[氧合指数(OI)、动脉血气分压比值(a/APO2)]与NCPAP参数[氧浓度分数(FiO2)、呼气末正压(PEEP)、吸气峰压(PIP)]变化。结果治疗前,两组OI、a/APO2、FiO2、PEEP、PIP水平比较差异无统计学意义;治疗后,两组OI、a/APO2水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组FiO2、PIP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。结论NCPAP与氨溴索联合治疗NRDS患儿可有效改善氧合指标与NCPAP参数,利于促进患儿身体恢复。

Objective To explore the effects of nasal continuous positive airway pressure(NCPAP)combined with ambroxol on oxygenation indexes and NCPAP parameters in children with neonatal respiratory distress syndrome(NRDS).Methods From February 2017 to December 2019,selected 80 patients with NRDS who were treated in our hospital as the research subject.They were divided into observation group and control group according to the random number table method,with 40 cases in each group.The control group was treated with NCPAP alone,and the observation group was treated with NCPAP combined with ambroxol.Compared the oxygenation index[oxygenation index(OI),arterial blood gas partial pressure ratio(a/APO2)]and NCPAP parameters[oxygen concentration fraction(FiO2),positive end-expiratory pressure(PEEP),inspiratory peak pressure(PIP)]changes before and after treatment in the two groups.Results Before treatment,there was no statistically significant difference in levels of OI,a/APO2,FiO2,PEEP,and PIP between the two groups;After treatment,the OI and a/APO2 levels of the two groups were higher than before treatment,and the observation group was higher than the control group,the difference was statistically significant(P<0.05);after treatment,the FiO2 and PIP levels of the two groups were lower than before treatment,and the observation group was lower,the difference was statistically significant(P<0.05).Conclusion NCPAP combined with ambroxol in the treatment of children with NRDS can effectively improve the oxygenation index and NCPAP parameters,which is beneficial to promote the children’s physical recovery.