创面自体富血小板联合血管介入治疗糖尿病足溃疡的疗效分析

Therapeutic effect of autologous platelet rich wound combined with vascular interventional therapy on diabetic foot ulcer

目的探究创面自体富血小板联合血管介入治疗糖尿病足溃疡(DFU)的临床疗效。方法选取2018年5月至2019年7月于本院就诊的DFU患者66例,通过随机数字表法分为观察组和对照组,每组33例。对照组患者接受单纯的自体富血小板凝胶(APG)进行创面治疗,观察组患者在对照组的基础上联合血管介入治疗,比较不同Wagner分级条件下,两组患者治疗效果及愈合时间。结果两组Wagner分级Ⅱ级患者治疗总有效率(观察组86.36%,对照组65.00%)比较差异无统计学意义;观察组Wagner分级Ⅲ级患者治疗总有效率(90.91%)明显高于对照组(46.15%),差异具有统计学意义(P<0.05);以两组显效例数作为愈合病例,观察组Wagner分级Ⅱ级患者愈合时间明显短于对照组,差异具有统计学意义(P<0.05);两组Wagner分级Ⅲ级患者愈合时间比较差异无统计学意义。结论 APG治疗DFU患者效果显著,但存在一定局限性,联合血管介入治疗方法后,可提高患者创面愈合率,加快其创面愈合时间。

Objective To explore the clinical effect of autologous platelet rich wound combined with vascular interventional therapy on diabetic foot ulcer(DFU). Methods A total of 66 cases of DFU patients admitted to our hospital from May 2018 to July 2019 were selected and divided into observation group and control group by random number table method, with 33 cases in each group. Patients in the control group received simple autologous platelets rich gel(APG) for wound treatment, while patients in the observation group received combined vascular interventional therapy on the basis of the control group. The total therapeutic efficiency and healing time between the two groups were compared under different Wagner grading conditions. Results There was no statistically significant difference in the total effective rate(86.36% in the observation group and 65.00% in the control group) of treatment between gradeⅡ patients with Wagner grading in the two groups. The total effective rate(90.91%) of patients with Wagner gradingⅢ in the observation group was significantly higher than that of the control group(46.15%), the difference was statistically significant(P<0.05). The number of significant cases in the two groups was taken as healing cases, and the healing time of patients with Wagner grading grade II in the observation group was significantly shorter than that in the control group, the difference was statistically significant(P<0.05). There was no significant difference in healing time between grade Ⅲ patients with Wagner grading in the two groups. Conclusion APG has a good effect in the treatment of DFU patients, but there are some limitations. Combined vascular interventional therapy can improve the wound healing rate and speed up the wound healing time of patients. However, the number of cases in this study is limited, and this conclusion needs to be further confirmed by multi-center and large sample study.