2018年仁寿县健康人群麻疹、风疹、流行性腮腺炎抗体水平监测

Antibody Levels of Measles,Rubella and Mumps in Healthy Population in Renshou County in 2018

目的了解仁寿县健康人群麻疹、风疹和流行性腮腺炎抗体水平,评价免疫接种效果,为制定和完善免疫规划策略提供科学依据。方法2018年采用分层随机抽样方法选择仁寿县210名健康人群采集血清标本,采用酶联免疫吸附试验(ELISA)定量测定血清中麻疹、风疹、流行性腮腺炎IgG抗体,同时调查社会人口学特征及免疫史等信息。结果210名检测对象中,麻疹、风疹、流行性腮腺炎抗体阳性率分别为90.00%、79.52%和65.71%,抗体几何平均浓度(GMC)分别为566.68 mIU/ml、32.95 IU/ml和48.95 IU/ml。不同性别、不同地区麻疹、风疹、流腮IgG抗体阳性率和GMC差异无统计学意义(P>0.05),但在不同年龄组之间差异有统计学意义(P<0.05)。麻疹、风疹、流腮抗体阳性率均随免疫剂次的增加而增加,差异均有统计学意义(P<0.05)。结论仁寿县麻疹、风疹抗体水平较高,但对5岁以上重点人群仍需提高和巩固相关疫苗接种率和免疫成功率。流行性腮腺炎抗体水平较低,应加强18~24月龄查漏补种工作,同时国家在2020-06-01调整免疫规划策略后,8月龄和18月龄儿童应及时接种麻腮风疫苗,以有效控制疾病的发生和流行。

Objective To learn about the antibody levels of measles,rubella and mumps in healthy people,to evaluate the effectiveness of immunization programs in Renshou County and to provide scientific evidence for formulating and improving immunization planning strategy.Methods A total of 210 healthy people in Renshou were randomly selected using stratified random sampling method in 2018.Serum samples were collected from all these subjects for testing lgG antibodies against measles,rubella and mumps using enzyme-linked immunposorbent assay(ELISA).And the information such as the characteristics of social demography and immune history were investigated at the same time.Results Among the 210 subjects,positive rate for measles,rubella and mumps antibody was 90.00%,79.52% and 65.71%;and the geometric mean concentration(GMC)was 566.68 mIU/ml,32.95 IU/ml and 48.95 IU/ml,respectively.The differences in the positive rate and GMC of measles,rubella and mumps IgG antibody in different genders and different places were not statistically significant(P>0.05),but it was statistically significant in different age groups(P<0.05).The positive rates of measles,rubella and mumps antibodies increased with the increase of immunization doses,and the differences were statistically significant(P<0.05).Conclusion The antibody levels of measles and rubella in Renshou County were high,but it is still necessary to improve and consolidate the relevant vaccination rate and immunization success rate for the key population over 5 years old.The antibody level of mumps was low,so it is necessary to strengthen the work of leakage detection and reinoculation among children at the age of 18-24 months.At the same time,after the national immunization planning strategy was adjusted on June1 st,2020,children at the age of 8 months and 18 months should be vaccinated with mumps vaccine in time to effectively control the occurrence and prevalence of the disease.