恩诺沙星、氟苯尼考和泰万菌素在鸡蛋中残留消除规律研究

Study on the elimination regularity of enrofloxacin, florfenicol and acetylisovaleryl tylosin residues in eggs

目的评估恩诺沙星、氟苯尼考和泰万菌素在鸡蛋中的残留消除规律。方法将80羽高产海兰褐蛋鸡随机等分成4组,对照组饲喂基础日粮,恩诺沙星组、氟苯尼考组和泰万菌素组分别经混饲给予相应药物,每日1次,连续给药5 d,停药19 d,检测各枚鸡蛋中相应药物及其主要代谢产物的残留量。结果恩诺沙星及其主要代谢产物环丙沙星与氟苯尼考及其主要代谢产物氟苯尼考胺可迅速残留于鸡蛋中,残留物分别以恩诺沙星原型和氟苯尼考原型为主,且其残留蓄积期都超过19 d。泰万菌素及其主要代谢产物3-乙酰胺基泰万菌素在鸡蛋中的残留总量低于最大允许残留限量,且平均残留蓄积期为7 d,3-乙酰胺基泰万菌素占总残留量的50%以上。结论恩诺沙星和氟苯尼考在海兰褐品系鸡蛋中残留消除周期超过19 d,在对后备蛋鸡、肉蛋兼用鸡给药时需严格控制用法用量。在适用情况下,可优先选择平均残留消除周期相对较短的泰万菌素。

Objective To evaluate the elimination regularity of enrofloxacin,florfenicol and acetylisovaleryl tylosin residues in eggs.Methods Eighty high-yield Hailanhe laying hens were randomly divided into 4 groups,the control group was fed basic diet,the enrofloxacin group,the florfenicol group and the tywanmycin group were given corresponding drugs once a day for 5 days,and 19 days withdrawal period was followed,the residual amount of the corresponding drugs and their main metabolites in each egg were detected.Results Enrofloxacin and its main metabolite ciprofloxacin and flufenicol and its main metabolite florfenicol amine could be quickly remained in eggs,the enrofloxacin prototype and florfenicol prototype were the mainly residue,the residue accumulation periods were more than 19 days.The total amount of acetylisovaleryl tylosin and its main metabolite 3-acetamidethyne in eggs were lower than the maximum allowable residue limits,and the average residual accumulation period was 7 days,and3-acetamidoxin accounted for more than 50% of the total residues.Conclusion The residual elimination periods of enrofloxacin and flufenicol are both more than 19 days in Hailanhe eggs,the usage and dosage should strictly controlled when they are treated for the reserve layer and chickens used for both meat and eggs.If it is applicable,the acetylisovaleryl tylosin,which with relatively short average residual elimination period,can be selected preferentially.