裸鼹鼠脑形态研究进展及应用展望

Research progress of brain morphology and function in naked mole-rats and application prospects

裸鼹鼠具有抗肿瘤、耐低氧、耐疼痛、寿命长等优势特性,近年来逐渐成为科研界的新星,但是其在神经科学领域的应用尚待进一步深入推广。本文通过对裸鼹鼠脑形态,及大脑结构中控制视觉、听觉、嗅觉、感觉等功能的中枢结构进行系统的描述,系统阐述裸鼹鼠在长期演化过程中对低氧、黑暗等地下环境所做出的的适应性改变。裸鼹鼠这一结构与功能相适应的特征性改变,有望使其成为研究神经系统疾病包括神经退行性病变等方面的优势动物模型,从而进一步推动人类健康医学的发展。

Recently,naked mole-rats have become increasingly used in scientific research because of their advantages in anti-tumor,anti-hypoxia,anti-pain and long life-span studies. In this article,we summarize the brain morphology of naked mole-rats,and systematically describe the central structures of the brain that control the functions of vision,hearing,olfactory sense and sensation,and the adaptation of naked mole-rats to low oxygen,darkness and other underground environments. The naked mole rat is expected to become a dominant animal model for the study of neurodegenerative diseases and other aspects of neurological disorders,and may promote the development of medicines for human neurological health in the future.