皮肤腐蚀和皮肤刺激替代试验的发展及其在化学品危险性分类的应用

Application of alternative tests of skin corrosion and irritation for chemical hazard classification

综述了皮肤腐蚀和皮肤刺激替代试验的发展,介绍了最近被列入《全球化学品统一分类和标签制度(全球统一制度)》(Globally Harmonized System of Classification and Labelling of Chemicals,GHS)的试验和评估综合策略(Integrated Approach on Testing and Assessment,IATA)。重点讨论了各种替代试验的原理、方法和适用范围,详细分析了各种替代试验方法在该策略应用中的优势和局限,为今后有效利用各种替代试验及其数据开展化学品皮肤腐蚀性和刺激性分类工作提供了指引。

The development of alternative tests for skin corrosion and skin irritation were reviewed,and the Integrated Approach on Testing and Assessment(IATA),which was recently adopted by the Globally Harmonized System of Classification and Labelling of Chemicals(GHS),was introduced.Focusing on the principles,Methods and scope of various alternative tests,the advantages and limitations of these tests in the application of IATA will be discussed to provide guidance for the classification of chemicals causing skin corrosion and irritation by effective utilization of the alternative tests and the data derived from these tests.