应激性胃溃疡相关信号通路的研究进展

Research progress of signaling pathways related to stress-induced gastric ulcers

应激性胃溃疡(SGU)是由于机体遭受应激,从而出现细胞代谢障碍和损伤,最终引起胃黏膜急性糜烂与溃疡的一种疾病。其发病机制尚不明确,了解与SGU相关的信号通路对进一步研究SGU的发病机制及寻找潜在的治疗靶点有重要意义。本文对与SGU相关的信号通路研究进展作一综述,发现SGU与JAK/STAT信号通路、Nrf2/HO-1信号通路、NF-κB信号通路、ERK1/2信号通路、Hedgehog信号通路、TLR信号通路、PI3K/Akt信号通路均关系密切。希望据此能够为SGU发病机制的研究及新兴治疗手段的提出提供一定的科学依据。

Stress-induced gastric ulcers(SGU)is a disease in which the body suffers from stress,Resultsing in cell metabolism disorders and damage,and eventually causing acute erosion and ulcers of the gastric mucosa.The pathogenesis of SGU is still unclear.Understanding the signaling pathways related to SGU is of great significance for further research into the pathogenesis of SGU and the search for potential therapeutic targets.This article reviews the research progress of SGU-related signal pathways,and shows that SGU and the JAK/STAT,Nrf2/HO-1,NF-κB,ERK1/2,Hedgehog,TLR,and PI3 K/Akt signaling pathways are closely related.The goal of this review is to provide a certain scientific basis for the study of the pathogenesis of SGU and potential new treatment method.