Toll样受体4信号途径在酒精性肝损伤中的作用研究进展

The role of the toll-like receptor 4 signaling pathway in alcoholic liver injury

柳叶刀发布的2019年中国疾病负担数据显示,饮酒是导致死亡的第10大危险因素。而由喝酒引发的酒精性肝损伤的发病机制十分复杂,至今仍无清晰定论。Toll样受体4信号途径在酒精性肝损伤的发生发展中有着深远的意义。因此,本文就Toll样受体4信号转导通路在酒精性肝损伤中的作用做一综述,为今后酒精性肝损伤的防治提供新的研究思路。

According to data on China’s disease burden in 2019 published by the Lancet,alcohol consumption is the 10 th leading risk factor for death. However,the pathogenesis of alcoholic liver injury caused by drinking is very complicated,and there is still no final conclusion. The toll-like receptor 4 signaling pathway has a key role in the occurrence and development of alcoholic liver injury. Therefore,this article reviews the role of the toll-like receptor 4 signal transduction pathway in alcoholic liver injury.