新疆乌鲁木齐市982例维吾尔族围绝经期女性代谢综合征发病情况及其危险因素分析

Prevalence of metabolic syndrome in 982 Uygur perimenopausal women in Urumqi,Xinjiang and its risk factors

目的调查新疆乌鲁木齐市维吾尔族围绝经期女性代谢综合征(MS)发病情况及危险因素。方法选取2019年1月至2020年6月新疆乌鲁木齐市982例围绝经期女性作为研究对象。根据是否存在MS分为MS组(n=240)和非MS组(n=742)。比较两组基线资料并进行单因素和多因素Logistic回归分析。结果新疆乌鲁木齐市982例围绝经期女性MS发生率为24.4%。MS组体重指数(BMI)、嗜油/盐比例、不规律锻炼比例、合并甲状腺减退症比例、雌激素水平降低比例、腰围、甘油三酯高于非MS组,25-羟基维生素D[25(OH)D]和高密度脂蛋白胆固醇水平低于非MS组,差异具有统计学意义(P<0.05)。Logistic回归分析显示,高BMI、嗜油/盐、缺乏规律锻炼、合并甲状腺功能减退症、雌激素水平降低和低水平25(OH)D是维吾尔族围绝经期女性发生MS的危险因素(OR=1.275,7.264,6.308,2.172,3.459,0.954,P<0.05)。结论新疆乌鲁木齐市维吾尔族围绝经期女性MS发生率较高,高BMI、嗜油/盐、缺乏规律锻炼、合并甲状腺功能减退症、性激素水平降低和低水平25(OH)D是其发生MS的危险因素,应从多个方面对维吾尔族围绝经期女性进行综合干预。

Objective To observe the prevalence and risk factors of metabolic syndrome(MS)in Uygur perimenopausal women in Urumqi,Xinjiang.Methods 982 perimenopausal women were selected from January 2019 to June 2020 in Urumqi,Xinjiang were selected and divided into MS group(n=240)and non-MS group(n=742).Univariate analysis and logistic regression model were used to analyze the risk factors of MS in perimenopaus-al women.Results The incidence of MS in 982 perimenopausal women in Urumqi,Xinjiang was 24.4%.Body mass index(BMI),the proportion of addicted to oil/salt,irregular exercise rate,combined hypothyroidism,de-creased estrogen level,waist circumference,triglycerides of the MS group are higher than those of the MS group,while the levels of 25-hydroxyvitamin D[25(OH)D]and high-density lipoprotein cholesterol are lower than those of the MS group(P<0.05).Logistic regression analysis showed that high BMI,oil/salt addiction,lack of regular ex-ercise,combined hypothyroidism,low estrogen level and low 25(OH)D were risk factors for MS in Uygur perim-enopausal women(OR=1.275,7.264,6.308,2.172,3.459,0.954,P<0.05).Conclusions The incidence of MS is high in Uygur perimenopausal women in Urumqi,Xinjiang.High BMI,oil/salt addict,lack of regular exer-cise,combined hypothyroidism,decreased estrogen level and low level of 25(OH)D are risk factors for MS in Uygur perimenopausal women.We should carry out comprehensive intervention on Uygur perimenopausal women.