乳腺癌术后放疗与全身系统治疗的顺序选择

Sequence selection of postoperative radiotherapy and systemic treatment for breast cancer patients

乳腺癌术后辅助治疗的作用是毋庸置疑的,合理布局术后放疗与辅助系统治疗既可以降低局部区域复发率,又可以提高患者生存率。部分系统治疗与放疗的最佳时序已经证实,但仍有方案需要进一步明确。特别是新辅助化疗者术后巩固化疗与术后放疗同步治疗的安全性、HER-2阳性患者术后双靶治疗与术后放疗同步治疗的安全性、小分子酪氨酸激酶抑制剂同步放疗的安全性等有待于进一步明确。本文对乳腺癌术后放疗与术后辅助系统治疗的顺序选择相关文献进行了综述。

The role of postoperative adjuvant therapy is crucial for breast cancer.Also,there is no doubt that the combination of effective postoperative radiotherapy and adjuvant systemic therapy can not only reduce the local recurrence rate,but also improve the survival rate of patients.Although the timing of postoperative radiotherapy and part of systemic therapy is clear,some part of treatment regimens still remain elusive.In particular,the safety of concurrent therapy of postoperative consolidation chemotherapy and postoperative radiotherapy in patients with neoadjuvant chemotherapy,the safety of concurrent therapy of postoperative dual-targeted therapy and postoperative radiotherapy in HER2-positive patients,and the safety of simultaneous radiotherapy of small molecule inhibitors need to be further clarified.This article reviews the related papers on the sequence selection of postoperative radiotherapy and postoperative adjuvant systemic therapy for breast cancer.