宜昌市HIV/AIDS抗病毒治疗前后CD4^(+)T淋巴细胞变化及影响因素

The changes and influencing factors of CD4^(+)T cell numbers during different periods of antiviral therapy in HIV/AIDS patients in Yichang City

目的分析宜昌市艾滋病感染者/艾滋病患者(HIV/AIDS)开展抗病毒治疗后CD4^(+)T淋巴细胞的变化情况。方法利用国家艾滋病综合防治信息系统-抗病毒治疗管理数据库收集相关信息,分析2003年1月1日至2017年12月31日期间在宜昌开始高效抗逆转录病毒治疗(HAART)并连续治疗满3年的HIV/AIDS CD4^(+)T细胞的变化情况。结果550例HIV/AIDS CD4^(+)T淋巴细胞数在治疗后的3年内各个时间点均有明显上升,并且有随着治疗时间的增加而增长(F=100.20,P<0.001),不同基线水平组的CD4^(+)T细胞计数在治疗前后组间两两比较差异有统计学意义(F=8.57,P<0.01),开始治疗年龄为15~30岁的患者CD4^(+)T淋巴细胞计数上升速度较30岁以上的患者快(F=1.27,P<0.05)。结论HAART对CD4^(+)T上升效果明显,早期治疗效果较好,应全面推进早检测、早诊断、早治疗工作,积极开展抗病毒治疗。

Objective To analyze the changes of CD4^(+)T cell numbers at different periods of antiviral therapy in HIV-infected and AIDS patients(HIV/AIDS)in Yichang City.Methods The relevant information was retrieved from the National AIDS Comprehensive Prevention Information System-Antiretroviral Treatment Management Database.Changes in the number of CD4^(+)T cells were analyzed in HIV/AIDS patients who started receiving highly active antiretroviral therapy(HAART)and continued the treatment for 3 years from January 1,2003 to December 31,2017 in Yichang.Results The number of CD4^(+)T lymphocytes in 550 HIV/AIDS cases increased significantly at various time points within 3 years after treatment,and increased with the increase of treatment time(F=100.20,P<0.001).The CD4^(+)T cell counts of different baseline level groups were statistically different before and after treatment(F=8.57,P<0.01).The CD4^(+)T cell counts of patients who started treatment at age of 15-30 years old increased faster than those who started treatment at age of over 30 years old(F=1.27,P<0.05).Conclusion HAART has a significant effect on the increase of CD4^(+)T cells,and the early treatment is more effective.Early detection,diagnosis and treatment should be promoted,and anti-viral treatment should be actively carried out.