血脂与非创伤性股骨头坏死行全髋关节置换术后下肢深静脉血栓的相关性分析

Correlation Analysis between Blood Lipids and Deep Venous Thrombosis of Low Limb in Patients with Non-Traumatic Osteonecrosis of the Femoral Head after Total Hip Arthroplasty

目的:评估非创伤性股骨头坏死(Osteonecrosis of the Femoral Head, ONFH)患者术前血脂水平与行全髋关节置换术(Total Hip Arthroplasty, THA)后下肢深静脉血栓(Deep Venous Thrombosis, DVT)发生的相关性。方法:2014年8月至2020年1月行THA术的ONFH患者共224例,所有患者均在术后第3天行双下肢静脉B超。根据检查结果分为DVT组(男12例,女18例,平均年龄60.63岁)和非DVT组(男84例,女110例,平均年龄57.97岁),通过多变量Logistic回归分析两组患者术前血清甘油三酯(Triglycerides, TG),总胆固醇(Total Cholesterol, TC),高密度脂蛋白胆固醇(High-density Lipoprotein Cholesterol, HDL-C)、低密度脂蛋白胆固醇(Low-density Lipoprotein Cholesterol, LDL-C)水平与术后DVT发生风险的相关性。结果:女性ONFH患者中,DVT组TG值明显高于非DVT组,差异有统计学意义(P=0.029),且高TG值与DVT的发生正相关(P=0.042)。结论:高TG水平是女性非创伤性ONFH患者行THA术后DVT发生的危险因素。

Objective:To evaluate the association of serum lipids and deep vein thrombosis(DVT) risk following total hip arthroplasty(THA) in patients with non-traumatic osteonecrosis of the femoral head(ONFH).Methods:A total of 224 non-traumatic ONFH patients who had undergone total hip arthroplasty(THA) underwent the color Doppler ultrasound of bilateral lower-extremities deep veins on 3 d postoperatively from August 2014 to January 2020.Based on the inspection results, patients were divided into DVT group(12 males and 18 females, mean age was 60.63 years old) and non-DVT group(84 males and 110 females, mean age was 57.97 years old).The association of serum triglycerides(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C) levels and postoperative DVT risk were analyzed by the multivariate Logistic analysis.Results:In females, DVT patients had a higher serum TG level than that in non-DVT patients(P=0.029) and a higher TG level was significantly associated with DVT(P=0.042).Conclusion:An increased TG level is a risk factor of DVT after THA in female non-traumatic ONFH patients.