猕猴结肠镜检查前的肠道准备

Bowel Preparation before Colonoscopy on Macaques

猕猴是非常重要且珍贵的实验动物。不处死猕猴为前提,以反复多次对猕猴进行全结肠肠道检查及研究为目的,建立猕猴全结肠内镜检查前的肠道准备方法尤为重要。本研究补充此方法目前尚无报道的空白。30只猕猴,结肠镜检查前3 h分多次予以芒硝溶液管喂。通过肠镜观察肠道清洁情况,其中3只猕猴肠道准备为Ⅲ级,其余猕猴肠道准备均为Ⅰ~Ⅱ级。所有猕猴在洗肠过程中,无严重脱水、休克、死亡等并发症发生,肠道准备为Ⅰ~Ⅱ级猕猴顺利完成全结肠内镜检查。

Macaques are very important and precious laboratory animals. The aim of this study was to examine the entire colon on alive macaques repeatedly. In order that,it is particularly important to establish a method about colon preparation before colonoscopy. But until now there are no reports on specific preparation method for colonoscopy on macaques. The aim of this study was to develop a method of bowel preparation before colonoscopy on macaques.Thirty macaques were fed with glauber’s salt through nasogastric tubes several times before colonoscopy. Intestinal cleansing was observed by colonoscopy. Three macaques were prepared for grade Ⅲ and the rest of the macaques were grade Ⅰ and grade Ⅱ. All macaques did not have serious complications such as dehydration,shock,and death during the process of washing the intestines. The colonoscopy was successfully completed on intestinal preparations of grade Ⅰ and grade Ⅱ macaques.