肿瘤相关成纤维细胞在肿瘤化疗耐药与转移中作用的研究状况

The role of cancer associated fibroblasts in chemotherapy resistance and metastasis of cancer

肿瘤微环境与肿瘤的发展、转移及耐药等相关密切,这方面的研究也越来越受到人们的关注。肿瘤相关成纤维细胞(CAFs)作为肿瘤微环境中的主要细胞类型,在肿瘤微环境中占基质细胞的比例很高,它们通过调节多种肿瘤相关信号通路,产生和分泌多种趋化因子和促进上皮间充质转化,从而促肿瘤的形成、增殖、侵袭和转移。本文将对CAFs与肿瘤耐药与转移的关系的研究进展做一综述,以便为肿瘤化疗耐药与转移提供解决思路,为提高肿瘤治疗疗效提供可能的新靶点。

Tumor microenvironment is closely related to the development,metastasis and drug resistance of tumors.More and more attention has been paid to the study of tumor microenvironment.As the main cell type in tumor microenvironment,cancer-associated fibroblasts(CAFs)account for a high proportion of stromal cells in tumor microenvironment.They produce and secrete a variety of chemokines and promote epithelial mesenchymal transformation by regulating a variety of tumor related signal pathways,thus promoting the formation,proliferation,invasion and metastasis of tumors.This article reviews the research progress of the relationship between CAFs and tumor drug resistance and metastasis,in order to provide new solutions for tumor chemotherapy resistance and metastasis,and provide possible new targets for improving the curative effect of tumor treatment.