益气活血法联合阿奇霉素治疗对慢性阻塞性肺疾病患者临床疗效、炎性因子及肺功能的影响

The effects of Yi-qi-huo-xue combined with azithromycin on clinical efficacy,inflammatory factors,and lung function of patients with chronic obstructive pulmonary disease

目的分析益气活血法联合阿奇霉素治疗对慢性阻塞性肺疾病(COPD)患者临床疗效、炎性因子以及肺功能的影响。方法2018年1月至2020年2月我院收治的79例COPD患者,根据不同治疗方法分为对照组39例(采用阿奇霉素治疗)和研究组40例(采用益气活血法联合阿奇霉素治疗)。比较两组临床疗效、治疗前后肺功能指标、炎性因子指标及动脉血气分析变化情况。结果治疗后研究组总有效率高于对照组(P<0.05);两组肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)、C-反应蛋白(CRP)、D-二聚体(D-Di)水平均低于治疗前,1秒用力呼气容积(FEV_1)、用力肺活量(FVC)、1秒用力呼气容积占用力肺活量的百分比(FEV_1/FVC%)、氧合指数(OI),动脉血氧分压(PaO_2)及动脉血氧饱和度(Sa O_2)高于治疗前,且研究组上述炎性因子水平低于对照组,FEV1、FVC、FEV_1/FVC%、OI、PaO_2、Sa O_2高于对照组(P<0.05)。结论益气活血法联合阿奇霉素治疗COPD患者疗效显著,可有效改善患者肺功能,降低炎症反应水平,改善高凝状态。

Objective To analyze the effects of the Yi-qi-huo-xue combined with azithromycin on the clinical efficacy,inflammatory factors,and lung function of patients with chronic obstructive pulmonary disease(COPD).Methods Seventy-nine COPD patients admitted to our hospital from January 2018 to February 2020 were involved in the study.According to different treatment methods,the patients were divided into a control group(n=39)and a study group(n=40).The control group was treated with azithromycin while the study group was treated with Yi-qi-huo-xue and azithromycin.The clinical efficacy and the changes in pulmonary function indexes,inflammatory factor indexes,and arterial blood gas analysis before and after treatment were compared between the two groups.Results After treatment,the total effective rate in the study group was significantly higher than that in the control group(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),C-reactive protein(CRP)and the D-Dimer(D-Di)in both groups were significantly lower than those before treatment.The forced expiratory volume in 1 second(FEV1),forced vital capacity(FVC),ratio of forced expiratory volume in 1 second to forced vital capacity(FEV1/FVC%),oxygenation index(OI),arterial oxygen partial pressure(PaO_(2)),and arterial oxygen saturation(SaO_(2))were significantly higher than those before treatment.The levels of the inflammatory factors were significantly lower while the pulmonary function indexes were higher in the study group than those in the control group(P<0.05).Conclusion The Yi-qi-huo-xue combined with azithromycin has a significant effect in the treatment of COPD patients.It can effectively improve the lung function,reduce the level of inflammatory factors,and improve the hypercoagulable state.