免疫治疗在甲状腺癌中的研究进展

Research progress of immunotherapy in thyroid cancer

近年来,随着免疫检查点抑制剂(ICIs)的开发应用,免疫治疗在肿瘤领域所发挥的作用越来越受到广泛关注,其在多种肿瘤中取得的良好效果也导致了晚期癌症患者治疗模式的转变。晚期及难治性甲状腺癌的恶性程度较高,缺乏有效的治疗手段,导致患者预后不良,免疫治疗可能成为一种具有前景的治疗选择使患者获益。目前,甲状腺癌的免疫治疗研究尚处于起步探索阶段。本文将对甲状腺癌的免疫特征、免疫治疗的作用机制及其在甲状腺癌中的研究进展进行综述。

In recent years,with the development of immune checkpoint inhibitors(ICIs),the role of immunotherapy in the field of cancer has attracted more and more attentions.The outstanding effect of immunotherapy in a broad spectrum of tumors has also led to a paradigm shift in therapy for patients with advanced cancer.Advanced and refractory thyroid cancer is highly malignant and lacks effective treatment,leading to a poor prognosis,while immunotherapy may be a promising treatment option to benefit patients.At present,the immunotherapy in thyroid cancer is still in the initial stage of exploration.This article will review the immune characteristics of thyroid cancer,and the mechanism and research progress of immunotherapy in thyroid cancer.