超声极速成像技术在痛风性关节炎患者颈动脉弹性功能检测中的应用

Detection of carotid artery elastic function with ultrafast ultrasound imaging technology in patients with gouty arthritis

目的探讨应用超声极速成像技术(UFUI)在测量痛风性关节炎(gouty arthritis,GA)患者颈动脉弹性中的临床应用价值。方法选取痛风性关节炎患者为GA组(102例),并根据是否合并骨质侵蚀情况,将GA组分为非骨质侵蚀组(52例)及骨质侵蚀组(50例)。另将同时期来我院体检的54例健康志愿者纳入对照组。比较全体受试者的血压、血脂、尿酸、颈动脉内-中膜厚度(IMT)、收缩期起始时脉搏波传导速度(BS)及收缩期结束时脉搏波传导速度(ES)等指标。结果(1)GA组尿酸、IMT、BS、ES较对照组明显增高(P<0.05),GA组年龄、体质指数、收缩压、舒张压、总胆固醇、甘油三酯及高密度脂蛋白胆固醇较对照组比较差异无统计学意义(P>0.05)。(2)GA组中,骨质侵蚀组BS、ES、病程明显高于非骨质侵蚀组(P<0.05),两亚组间IMT、年龄、体质指数、血压、血脂、尿酸比较差异无统计学意义(P>0.05)。(3)GA组患者BS、ES分别与IMT呈正相关。对照组、非骨质侵蚀组、骨质侵蚀组BS分别为(5.12±0.76)m/s、(5.90±0.84)m/s、(6.81±0.76)m/s,ES分别为(6.93±0.96)m/s、(8.60±1.19)m/s、(9.50±0.79)m/s。结论痛风性关节炎患者BS及ES增高,颈动脉硬度增高、弹性下降。UFUI技术可以早期发现痛风性关节炎患者颈动脉弹性功能变化,为临床早期评估颈动脉粥样硬化提供重要参考依据。

Objective carotid artery elasticity in patients with gouty arthritis(GA).Methods and according to whether combined with bone erosion,they were divided into non-bone erosion GA group(n=52)and bone erosion GA group(n=50).In addition,54 healthy volunteers in our hospital for physical examination during the same period were included in the control group.Blood pressure,blood lipids,uric acid,carotid arterymedia thickness(IMT),pulse wave velocity at the beginning of the systole(BS),and at the ending of the systole(ES)in all the participants were compared.Results(1)Uric acid,IMT,BS and ES in the GA group were significantly higher than those in the control group(P<0.05).There was no difference in age,body mass index,systolic blood pressure,diastolic blood pressure,total cholesterol,triglycerides and high-density lipoprotein cholesterol in the GA group when compared with the control group(P>0.05).(2)In the GA group,the BS,ES and the course of the disease of the bone erosion group were significantly higher than those of the non-bone erosion group(P<0.05).There was no difference in IMT,age,body mass index,blood pressure,blood lipids and uric acid between the two subgroups(P>0.05).(3)BS and ES of GA group were positively correlated with IMT.The pulse wave velocity at the beginning of the systole of the control group,the non-bone erosion GA group and the bone erosion GA group were(5.12±0.76)m/s,(5.90±0.84)m/s and(6.81±0.76)m/s,respectively.The pulse wave velocity at the ending of the systole of the control group,the non-bone erosion GA group and the bone erosion GA group were(6.93±0.96)m/s,(8.60±1.19)m/s and(9.50±0.79)m/s,respectively.Conclusion increased in GA patients;carotid artery stiffness is increased and the elasticity is down.UFUI technology can detect the changes of carotid artery elastic function in GA patients in the early time,which provides important reference for early clinical evaluation of carotid atherosclerosis.