碳酸锂联合喹硫平治疗双相情感障碍的效果与安全性

Efficacy and safety of lithium carbonate combined with quetiapine in treatment of bipolar disorder

目的 探讨碳酸锂联合喹硫平治疗双相情感障碍的效果。方法 随机数表法将本院2018年3月至2020年3月收治的96例双相情感障碍患者分为对照组和观察组,各48例。对照组给予碳酸锂治疗,观察组行碳酸锂联合喹硫平治疗,均治疗8周,对两组疗效、炎症因子水平、用药安全性及患者躁狂程度进行评价。结果 两组治疗总有效率分别为87.50%和70.83%,观察组高于对照组,差异有统计学意义(P<0.05)。观察组的不良反应发生率低于对照组,差异有统计学意义(P<0.05)。治疗前,观察组IL-1(118.69±19.14)ng/L、TNF-α(160.26±37.45)ng/L,对照组IL-1(117.39±20.66)ng/L、TNF-α(114.28±32.55)ng/L;两组IL-1、TNF-α较治疗前下降,IL-10提高,差异有统计学意义(P<0.05),观察组治疗后IL-1、TNF-α低于对照组,IL-10高于对照组,两组比较差异有统计学意义(P<0.05)。治疗1、4、8周后观察组BRMS评分为(24.19±5.58)、(18.26±4.19)及(10.29±3.49)分,对照组分别为(29.47±6.00)、(23.55±4.36)及(16.29±3.61)分,与治疗前比下降,差异有统计学意义(P<0.05),且观察组BRMS评分均低于对照组,差异有统计学意义(P<0.05)。结论 碳酸锂联合喹硫平治疗双相情感障碍,效果显著,可改善患者炎症因子水平和躁狂症状,安全可靠。

Objective To explore the effect of lithium carbonate combined with quetiapine in the treatment of bipolar disorder.Methods Ninety-six patients with bipolar disorder admitted to our hospital from March 2018 to March 2020 were divided into the control group and the observation group by random number table method,with 48 patients in each group.The control group were treated with lithium carbonate,and the observation group were treated with lithium carbonate combined with quetiapine.Both groups were treated for 8 weeks.The efficacy,inflammatory factor levels,drug safety and degree of mania of the two groups were evaluated.Results The treatment efficiencies of the two groups was 87.50%and 70.83%,respectively.The treatment efficacy of the observation group was higher than that of the control group,with statistically significant difference(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).Before treatment,the levels of IL-1 and TNF-αin the observation group were(118.69±19.14)ng/L and(160.26±37.45)ng/L,and those in the control group were(117.39±20.66)ng/L and(114.28±32.55)ng/L.The levels of IL-1 and TNF-αin both groups were decreased and the levels of IL-10 were increased compared with those before treatment,with statistically significant differences(P<0.05).After treatment,the levels of IL-1 and TNF-αin the observation group were lower than those in the control group,and the level of IL-10 in the observation group was higher than that in the control group,with statistically significant differences(P<0.05).After 1,4,and 8 weeks of treatment,the BRMS scores of the observation group were(24.19±5.58),(18.26±4.19)and(10.29±3.49)points,and those of the control group were(29.47±6.00),(23.55±4.36)and(16.29±3.61)points,which were decreased compared with those before treatment,with statistically significant differences(P<0.05).The BRMS score of the observation group was lower than that of the control group,with statistically significant difference(P<0.05).Conclusion Lithium carbonate combined with quetiapine has a significant effect in the treatment of bipolar disorder,which improves the level of inflammatory factors and symptoms of mania.It is safe and reliable.