两种用药方案治疗首发型中青年抑郁症的效果与安全性比较

Comparison of efficacy and safety of two medication regimens in the treatment of first-onset depression in young and middle-aged people

目的 观察不同用药方案治疗首发型中青年抑郁症的效果并评价其安全性。方法 选取2018年9月至2020年3月在我院确诊并接受治疗的首发型中青年抑郁症患者82例,按照随机数字表法分为观察组(n=41)和对照组(n=41)。对照组行氢溴酸西酞普兰治疗,观察组联合小剂量盐酸氟西汀治疗,连续治疗10周。比较两组患者的治疗有效性、服药前后的汉密顿抑郁量表17项(HAMD-17)、抑郁自评量表(SDS)、认知功能、日常生活能力评分及药物副反应发生情况。结果 观察组的治疗总有效率高于对照组,药物副反应发生率低于对照组,差异均有统计学意义(P<0.05);服药后,两组患者的HAMD-17、SDS评分均较服药前有所降低,且观察组低于对照组;认知功能及生活能力评分均较服药前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论 氟西汀联合氢溴酸西酞普兰在治疗首发型中青年抑郁症时效果更佳,能够显著改善患者认知功能,增强日常生活能力,且安全性更高,值得推广。

Objective To observe the efficacy of different medication regimens in the treatment of first-onset depression in young and middle-aged people and evaluate their safety.Methods Eighty-two young and middle-aged patients with depression diagnosed and treated in our hospital from September 2018 to March 2020 were selected.According to the digital table method,they were randomly divided into the observation group(n=41)and the control group(n=41).The control group was treated with citalopram hydrobromide,while the observation group was treated with low-dose fluoxetine hydrochloride combined with citalopram hydrobromide.Both groups were treated for 10 weeks.The efficacy of treatment,Hamilton Depression Scale 17(HAMD-17),Self-rating Depression Scale(SDS),cognitive function,scores of Ability of Daily Life(ADL),and the occurrence of medication side effects were compared between the two groups before and after taking medicine.Results The overall response rate was higher in the observation group than that in the control group,and the incidence of medication side effects was lower in the observation group than that in the control group,with statistically significant differences(P<0.05).After taking medicine,the scores of HAMD-17 and SDS in the two groups were lower than before,and the scores of HAMD-17 and SDS were lower in the observation group than those in the control group.The scores of cognitive function and ADL of two groups were higher than before,and the scores of cognitive function and ADL were higher in the observation group than those in the control group,with statistically significant differences(P<0.05).Conclusion Fluoxetine combined with citalopram hydrobromide is more effective in the treatment of first-onset young and middle-aged depression.It can significantly improve the cognitive function,enhance ADL of patients,and has higher safety,which is worth popularizing.