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Th17和Treg细胞在复发性流产发病机制中的研究进展 被引量:4

Progress in the role of Th17 cells and Treg cells in mechanism of recurrent spontaneous abortion
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摘要 复发性流产(RSA)是人类早孕常见的妊娠并发症。父母或胚胎染色体异常、生殖器异常、内分泌异常、抗磷脂综合征、免疫功能异常被认为是RSA的常见原因,但越来越多的研究表明,RSA与母胎免疫耐受的失衡密切相关。CD4+T细胞分泌的Th17细胞和CD4+CD25+调节性T细胞(Treg细胞)对于维持母胎免疫耐受平衡起着关键性的作用。当母体免疫平衡被打破,母体对胎儿的排斥作用增强,则可能引起流产。本文主要对Th17细胞和Treg细胞在RSA发病机制的作用进行综述。
作者 张惠芳 孙晓彤 何西彦 鲁蕃 杨莉莉 Zhang Huifang;Sun Xiaotong;He Xiyan;Lu Fan;Yang Lili
出处 《甘肃医药》 2021年第10期865-868,876,共5页 Gansu Medical Journal
基金 甘肃省卫生行业科研计划项目(项目编号:GSWSKY2016-48)。
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