一氧化氮信号通路与动脉粥样硬化

Nitric Oxide Signaling Pathway and Atherosclerosis

动脉粥样硬化(AS)是血管内的一种慢性炎症性疾病。由AS引起的心脑血管病是致患者死亡的首要原因。内皮型一氧化氮合酶(eNOS)和神经元型一氧化氮合酶(nNOS)合成适量的一氧化氮(NO)具有抗AS的作用,而诱导型一氧化氮合酶(iNOS)合成过多的NO,具有促进AS发生和发展的作用。鉴于NO在血管内皮细胞中的重要作用,本文就近年来NO信号通路与AS发病机制的研究进展进行综述,为研究临床治疗AS的NO相关药物提供参考。

Atherosclerosis(AS)is a chronic intravascular inflammatory disease.Cardiovascular and cerebrovascular diseases caused by are the leading cause of death in patients.The moderate amount of nitric oxide(NO)produced by endothelial nitric oxide synthase and neuronal nitric oxide synthase has anti-AS effects.However,the inducible nitric oxide synthase can synthesize excessive NO,which promotes AS development and development.Given the important role of NO in endothelial cells,this paper reviews the research progress in NO signaling pathway and AS pathogenesis,aiming to provide reference for clinical treatment of AS with NO-related drugs.