非酒精性脂肪性肝病对肠道免疫细胞的影响

Impact of nonalcoholic fatty liver disease on intestinal immune cells

由于肠肝循环以及免疫细胞募集、再循环特性,非酒精性脂肪性肝病(NAFLD)与肠道免疫系统相互影响。肠道免疫失衡促进NAFLD肝脏炎症及纤维化,而NAFLD能够引起肝脏及肠道免疫细胞数量及功能紊乱。主要阐述NAFLD对肠道免疫细胞的影响,简述以肠道免疫细胞为靶点的NAFLD治疗新手段,以期对NAFLD发病及治疗提供新认识。

Nonalcoholic fatty liver disease(NAFLD)interacts with the intestinal immune system due to enterohepatic circulation and immune cell recruitment and recirculation.Intestinal immune imbalance promotes liver inflammation and fibrosis in the process of NAFLD,and meanwhile,NAFLD can cause disorders in the number and function of immune cells in the liver and intestinal tract.This article mainly elaborates on the impact of NAFLD on intestinal immune cells and briefly summarizes the new treatment methods for NAFLD targeting at intestinal immune cells,in order to provide a new understanding of the pathogenesis and treatment of NAFLD.