N^(6)-甲基腺嘌呤甲基化在肝脏疾病中的作用

Role of N^(6)-methyladenosine methylation in liver diseases

N^(6)-甲基腺嘌呤(m6A)是存在于多种RNAs中的化学修饰方式,最常见于mRNA。肝脏是机体重要的代谢和消化器官,m6A甲基化在肝脏生理病理过程中发挥着重要作用。简述了m6A甲基化在肝脏生理和病毒性肝炎、非酒精性脂肪性肝病、肝纤维化以及肝细胞癌等肝脏疾病中的生物学作用及潜在应用价值,指出m6A甲基化可调控相关因子,参与肝脏疾病的发生发展,为其临床诊疗提供新的思路和靶点。

N^(6)-methyladenosine(m6A)is a chemical modification that exists in a variety of RNAs and is most commonly observed in mRNA.The liver is a vital metabolic and digestive organ in human body,and m6A methylation plays an important role in the physiological and pathological processes of the liver.This article reviews the biological role and potential application value of m6A methylation in liver physiology and liver diseases such as viral hepatitis,nonalcoholic fatty liver disease,liver fibrosis,and hepatocellular carcinoma,and it is pointed out that m6A methylation can regulate related factors and is involved in the development and progression of liver diseases,which provides new ideas and targets for clinical diagnosis and treatment.