基于数据挖掘探讨袁红霞治疗胃癌前病变用药规律

Administration Rules of YUAN Hongxia in Treating Precancerous Lesions of Stomach Cancer Based on Data Mining

目的:通过数据挖掘技术,分析袁红霞教授治疗胃癌前病变的用药规律。方法:收集105例有效病例的处方,运用古今医案云平台(V2.2.3)软件中的频次统计、中药属性分析、关联规则分析、聚类分析等方法进行数据挖掘,分析用药规律及特点。结果:105首处方中,使用频次≥15次的药物共31味,药味多苦、辛、甘,性温、平,主要归脾、胃、肺经。得出常用药对,前7位依次是生姜-大枣、炙甘草-半夏、大枣-半夏、柴胡-半夏、黄芩-半夏、生姜-半夏、柴胡-黄芩。得到核心组合3个。结论:袁红霞教授认为脾胃虚弱,气、血、水失调是胃癌前病变的主要病机,证型以中虚气逆证多见,临证用药当平缓柔和,通过健脾和胃,调节气、血、水的正常运行以调治胃癌前病变。

Objective: To analyze the administration rules of Prof. YUAN Hongxia in treating precancerous lesions of stomach cancer by data mining technology. Methods:The prescriptions of 105 valid cases were collected,and the methods of frequency statistics,attribute analysis of Chinese herbs,association analysis and cluster analysis in Ancient and Modern Medical Cases Cloud Platform(V2.2.3) were used for data mining to analyze the rule and characteristics of administration.Results: Among the 105 prescriptions, there were 31 kinds of herbs which were used more than 15 times, and their medicinal flavors were mainly bitter,acrid and sweet;their properties were warm and neutral;and they entered into the spleen, stomach and lung meridians. The top seven herbal pairs were Rhizoma Zingiberis Recens-Fructus Jujubae,Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle-Rhizoma Pinelliae, Fructus Jujubae-Rhizoma Pinelliae, Radix Bupleuri-Rhizoma Pinelliae,Radix Scutellariae-Rhizoma Pinelliae,Rhizoma Zingiberis Recens-Rhizoma Pinelliae,and Radix Bupleuri-Radix Scutellariae. Three core combinations were obtained by evolution. Conclusion:Prof. YUAN believes that the weakness of spleen and stomach and the imbalance of qi, blood and water are the main pathogenesis of precancerous lesions,and the main syndrome is deficiency of middle energizer and qi counterflow. In clinical prescription,the herbs used should be neutral and soft,strengthening the spleen and stomach and regulating the normal movement of qi,blood and water to regulate precancerous lesions.