经皮卵圆孔未闭封堵术降低隐源性脑卒中复发率的回顾性随访观察

Retrospective cohort study of percutaneous patent foramen ovale occlusion for reducing the recurrence rate of cryptogenic stroke

目的评估经皮介入封堵术在降低隐源性脑卒中患者脑卒中复发率的效果。方法回顾性纳入武汉亚洲心脏病医院2016年1月至2017年12月新诊断的隐源性脑卒中合并卵圆孔未闭患者188例,根据是否进行经皮卵圆孔封堵分为封堵组和非封堵组,术后随访2年,观察两组患者的脑卒中复发率。结果188例患者中104例行经皮卵圆孔未闭介入封堵术,101例封堵成功,成功率97%,无严重并发症,术后2年均没有复发脑卒中,无死亡患者。非封堵组84例,随访2年复发21例,复发率25%。结论经皮卵圆孔未闭介入封堵术可有效降低患者脑卒中复发率,且手术成功率较高,并发症较少,术后不需长期抗血小板治疗。

Objectives To evaluate the effect of percutaneous patent foramen ovale occlusion in reducing the recurrence rate of cryptogenic stroke in patients.Methods Totally 188 patients with newly diagnosed stroke combined with patent foramen ovale from January 2016 to December 2017 in Wuhan Asia Heart Hospital were retrospectively included.According to whether transcutaneous closure of patent foramen ovale was performed,they were divided into closure group and non-closure group.After 2 years of follow-up,the recurrence rates of stroke in the two groups were observed.Results Among the 188 patients,104 cases underwent patent foramen ovale closure,101 cases were successful,with a success rate of 97%.There were no serious complications.There was no recurrence of stroke or death in 2 years after the closure.In non-closure group,84 cases recurred in 2 years,the recurrence rate was 25%.Conclusions Patent foramen ovale closure can effectively reduce the recurrence rate,and the success rate of the closure is high,the complications are less,and the long-term antiplatelet treatment is not needed after the closure.