实体器官移植后移植物长期存活评估相关生物标志物研究进展

Research progress on biomarkers related to long- term graft survival evaluation after solid organ transplantation

随着器官移植手术技术的成熟,实体器官移植物长期存活逐渐成为移植术后的首要任务。实体器官移植后移植物功能丢失的主要原因是慢性移植物损伤,但其潜在机制尚不明确。移植物病理活检是用于诊断移植物功能状况的金标准,但因活检穿刺操作的侵入性以及取样的局限性,阻碍移植物功能状况的常规评估。因此,微损伤非侵入性样品(例如外周血或尿液)功能性监测,更利于实体器官移植术后移植物的管理。本文对实体器官移植中移植物长期存活的生物标志物研究进展作一综述。

With the maturity of organ transplantation technology,the long-term survival of solid organ grafts has gradually become the primary task after transplantation.The main cause of graft function loss after solid organ transplantation is chronic graft damage.However,its potential mechanism is not clear.Graft pathological biopsy is the gold standard for the diagnosis of graft function,but the routine evaluation of graft function is hindered by the invasiveness of biopsy puncture and the limitation of sampling.Therefore,functional monitoring of micro injury non-invasive samples(such as peripheral blood or urine)is more conducive to the management of grafts after solid organ transplantation.This paper will systematically review the literature on biomarkers of long-term graft survival in solid organ transplantation.