摘要
随着器官移植手术技术的成熟,实体器官移植物长期存活逐渐成为移植术后的首要任务。实体器官移植后移植物功能丢失的主要原因是慢性移植物损伤,但其潜在机制尚不明确。移植物病理活检是用于诊断移植物功能状况的金标准,但因活检穿刺操作的侵入性以及取样的局限性,阻碍移植物功能状况的常规评估。因此,微损伤非侵入性样品(例如外周血或尿液)功能性监测,更利于实体器官移植术后移植物的管理。本文对实体器官移植中移植物长期存活的生物标志物研究进展作一综述。
With the maturity of organ transplantation technology,the long-term survival of solid organ grafts has gradually become the primary task after transplantation.The main cause of graft function loss after solid organ transplantation is chronic graft damage.However,its potential mechanism is not clear.Graft pathological biopsy is the gold standard for the diagnosis of graft function,but the routine evaluation of graft function is hindered by the invasiveness of biopsy puncture and the limitation of sampling.Therefore,functional monitoring of micro injury non-invasive samples(such as peripheral blood or urine)is more conducive to the management of grafts after solid organ transplantation.This paper will systematically review the literature on biomarkers of long-term graft survival in solid organ transplantation.
作者
胡正斌
周鑫
熊艳
范晓礼
范志鹏
叶啟发
Hu Zhengbin;Zhou Xin;Xiong Yan;Fan Xiaoli;Fan Zhipeng;Ye Qifa(Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,National Quality Control Center for Donated Organ Procurement,Hubei Key Laboratory of Medical Technology on Transplantation,Hubei Clinical Research Center for Natural Polymer Biological Liver,Hubei Engineering Center of Natural Polymer-based Medical Materials,WuHan 430071,China;Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology,Transplantation center of Xiangya Third Hospital of Central South University,Changsha 410013,China)
出处
《中华移植杂志(电子版)》
CAS
2021年第4期244-249,共6页
Chinese Journal of Transplantation(Electronic Edition)
基金
国家自然科学基金(81970548)
医学腾飞计划——“转化医学、医学+平台建设项目”(临床医学)(TFLC2018003)
武汉市科技计划项目(2019020701011485)。