川芎嗪联合银杏二萜内酯葡胺治疗脑梗死恢复期临床研究

Clinical Study of Ligustrazine Combined with Ginkgo Diterpene Lactone Meglumine in the Treatment of Cerebral Infarction in the Recovery Period

目的探讨川芎嗪注射液联合银杏二萜内酯葡胺注射液治疗痰瘀阻络型脑梗死恢复期效果。方法选择62例痰瘀阻络型脑梗死恢复期患者,根据治疗方法不同分为对照组30例(采用川芎嗪注射液治疗)和研究组32例(在对照组基础上采用银杏二萜内酯葡胺注射液治疗),观察2组治疗前后中医证候评分、美国卫生研究院卒中量表(NIHSS)评分和巴氏量表(BI)评分、不良反应。结果治疗前1 d,2组中医证候评分、NIHSS评分和BI评分对比差异无统计学意义(P>0.05);治疗15 d后,2组NIHSS评分、中医证候评分均降低(P<0.05),且研究组更低(P<0.05),2组BI评分均升高(P<0.05),且研究组更高(P<0.05)。2组治疗期间不良反应发生率相近(P>0.05)。结论对痰瘀阻络型脑梗死恢复期患者采用川芎嗪注射液联合银杏二萜内酯葡胺注射液治疗效果显著,且安全可靠。

Objective To investigate the clinical effect of ligustrazine injection combined with ginkgo diterpene lactone injection in the treatment of phlegm stasis obstructing collateral cerebral infarction in the recovery period.Methods A retrospective analysis method was used to select 62 patients with phlegm stasis obstructing collateral type cerebral infarction in the recovery period as the research objects.According to different treatment methods,they were divided into control groups(used ligustrazine injection)of 30 cases and the study group(used ginkgo diterpene lactone injection on the basis of the control group treatment)of 32 cases.The scores of traditional Chinese medicine syndrome,the National Institutes of Health Stroke Scale(NIHSS)scores and the Pap Scale(BI)index scores of the two groups before and after treatment were observed,the medical records were checked,and the adverse reactions that occurred during the treatment of the two groups were recorded and compared.Results 1 day before treatment,there was no significant difference between the two groups of traditional Chinese medicine syndrome scores,NIHSS scores and BI scores(P>0.05).After 15 days of treatment,the NIHSS scores and traditional Chinese medicine syndrome scores of the two groups decreased(P<0.05),and those of the study group were lower(P<0.05).After 15 days of treatment,BI scores in both groups increased(P<0.05),and that of the study group was higher(P<0.05).The incidence of adverse reactions during treatment in the two groups was similar(P>0.05).Conclusion The use of ligustrazine injection combined with ginkgo diterpene lactone injection in the treatment of phlegm stasis obstructing collateral cerebral infarction in the recovery period has significant effect,and it is safe and reliable.