已上市MEK抑制剂合成路线综述

Review of Synthetic Routes of Marketed MEK Inhibitors

丝裂原活化的细胞外信号调节激酶(MEK)抑制剂是重要的抗肿瘤药物,目前已上市4个产品,分别是曲美替尼、考比替尼、司美替尼和比美替尼。本文简要介绍了这4种药物,并对已报道的合成路线进行综述。

Mitogen-activated extracellular signal-regulated kinase(MEK)inhibitors are important antineoplastics.At present,four drugs have been marketed,namely trametinib,cobimetinib,selumetinib and binimetinib.This paper briefly introduces these drugs and reviews their reported synthetic routes.