江苏省2005-2019年接受抗病毒治疗的HIV/AIDS合并HBV感染情况分析

Analysis on HIV and hepatitis B virus coinfection in HIV/AIDS cases newly received highly active antiretroviral therapy in Jiangsu province,2005-2019

目的分析2005-2019年江苏省抗病毒治疗的HIV/AIDS的HBV感染情况。方法采用回顾性资料分析,研究对象来源于中国疾病预防控制信息系统艾滋病防治基本信息系统江苏省2005-2019年HIV/AIDS首次入组抗病毒治疗数据库,采用SPSS 16.0软件进行统计学分析。分析不同特征HIV/AIDS的HBsAg检测率和HBsAg阳性率的差异及其影响因素,单因素分析采用χ^(2)检验,多因素分析采用非条件logistic回归模型。结果 2005-2019年江苏省首次入组抗病毒治疗的HIV/AIDS共29 288例,总体HBsAg检测率为49.8%(14 594/29 288),2005-2019年HBsAg检测率由0.0%(0/80)增加到75.2%(3 448/4 586),呈逐年上升趋势。进行HBsAg检测的HIV/AIDS中,江苏省籍占81.6%(11 915/14 594),男女性别比7.34∶1(12 845∶1 749),年龄(38.5±13.8)岁,汉族占96.1%(14 023/14 594),已婚/同居占48.9%(7 131/14 594)。男男性传播和异性性传播感染途径占97.9%(14 294/14 594)。logistic回归分析结果显示,HBsAg检测率的影响因素中,2015年及以后入组、外省户籍、已婚/同居、大专及以上文化程度、注射吸毒感染途径的人群HBsAg检测率较高。HIV/AIDS的HBsAg阳性率为8.6%(95%CI:8.2%-9.1%),HBsAg阳性率在2016年之前均>10.0%,自2016年以后稳定在6.7%-8.2%。HBsAg阳性率的影响因素中,2015年及以后入组、女性、年龄>59岁、大专及以上学历人群的HBsAg阳性率较低,而45-59岁年龄组和少数民族人群的HBsAg阳性率较高。结论 2005- 2019年江苏省首次入组抗病毒治疗的HIV/AIDS中,HBsAg检测率总体不高,合并HBV感染高于一般人群,需要加强其HBsAg相关检测工作。

Objective To analyze the HIV and HBV coinfection in HIV/AIDS cases who newly received highly active antiretroviral therapy during 2005-2019 in Jiangsu province.Methods According to the base data of HIV/AIDS cases on HAART enrolled between January 2005 and December 2019;the National Information system was retrospectively collected for HIV/AIDS Control and Prevention of Chinese System Disease for Control and Prevention.Excel database was established,and statistical analysis was performed using the SPSS 16.0 software.A Chi-square test was used to assess differences in rates of HBsAg testing and HIV/HBV coinfection between potential risk factors.The unconditional logistic regression model entered risk factors with P values<0.05 in the Chi-square test.Results There were 29288 HIV/AIDS cases newly received HAART during 2005-2019.The rate of HBsAg test was 49.8%(14594/29288)the rate of HBsAg test increased from 0.0%(0/80)to 75.2%(3448/4586),showing an increasing trend year by year during 2005 to 2019.Among HIV/AIDS cases tested HBsAg,81.6%(11915/14594)cases were from Jiangsu province;the ratio of male to female was 7.34∶1(12845∶1749),the average age was(38.5±13.8)years old,96.1%(14023/14594)were Han nationality,48.9%(7131/14594)of the HIV/AIDS cases married,97.9%(14294/14594)were infected with HIV through homosexual and heterosexual transmission.Unconditional logistic regression modeling showed that the proportion of HIV/AIDS cases initiated HAART in 2015 or after that,married,not Jiangsu province resident,college education or above,and drug injection infected were more likely to have HBsAg testing.8.6%(95%CI:8.2%-9.1%)were HBsAg positive.The HIV and HBV coinfection rates were more than 10%before 2016 while showed stability from 6.7%to 8.2%since 2016.Unconditional logistic regression modeling showed that the proportion of HIV/AIDS cases who were male,elder,married,non-Han,primary education or below were more likely to have HBV coinfection.Conclusion More HBsAg testing should be strengthened when the HIV/AIDS cases initiated HAART in Jiangsu province,2005-2019.